Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 835298..835955 Replicon chromosome
Accession NZ_CP069203
Organism Klebsiella pneumoniae strain SP968

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag IEE96_RS04185 Protein ID WP_002916310.1
Coordinates 835545..835955 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IEE96_RS04180 Protein ID WP_002916312.1
Coordinates 835298..835564 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IEE96_RS04155 (830454) 830454..831887 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
IEE96_RS04160 (832006) 832006..832734 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
IEE96_RS04165 (832784) 832784..833095 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
IEE96_RS04170 (833259) 833259..833918 + 660 WP_002916317.1 hemolysin III family protein -
IEE96_RS04175 (834069) 834069..835052 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
IEE96_RS04180 (835298) 835298..835564 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
IEE96_RS04185 (835545) 835545..835955 + 411 WP_002916310.1 protein YgfX Toxin
IEE96_RS04190 (835962) 835962..836483 - 522 WP_004144730.1 flavodoxin FldB -
IEE96_RS04195 (836584) 836584..837480 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
IEE96_RS04200 (837503) 837503..838216 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IEE96_RS04205 (838222) 838222..839955 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T190075 WP_002916310.1 NZ_CP069203:835545-835955 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T190075 NZ_CP091068:c5382072-5381689 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT190075 WP_002916312.1 NZ_CP069203:835298-835564 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT190075 NZ_CP091068:c5382314-5382072 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References