Detailed information of TA system TA190071

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 5194104..5194609
• Replicon: chromosome
• Accession: NZ_CP069198
• Organism: Pseudomonas aeruginosa strain 152962

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JQM61_RS24430
• Protein ID: WP_034037564.1
• Coordinates: 5194328..5194609 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: JQM61_RS24425
• Protein ID: WP_003083775.1
• Coordinates: 5194104..5194331 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQM61_RS24400	5189122..5190615	+	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
JQM61_RS24405	5190784..5192211	+	1428	WP_003083784.1	GABA permease	-
JQM61_RS24410	5192293..5192634	-	342	WP_003101229.1	alkylphosphonate utilization protein	-
JQM61_RS24415	5192707..5193207	-	501	WP_003101228.1	LEA type 2 family protein	-
JQM61_RS24420	5193308..5193928	+	621	WP_034037566.1	hypothetical protein	-
JQM61_RS24425	5194104..5194331	+	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
JQM61_RS24430	5194328..5194609	+	282	WP_034037564.1	type II toxin-antitoxin system toxin ParE	Toxin
JQM61_RS24435	5194909..5195817	+	909	WP_016561475.1	LysR family transcriptional regulator	-
JQM61_RS24440	5195849..5196235	-	387	WP_014602345.1	aegerolysin family protein	-
JQM61_RS24445	5196439..5197173	-	735	WP_003117208.1	GntR family transcriptional regulator	-
JQM61_RS24450	5197274..5197960	-	687	WP_003083762.1	FadR family transcriptional regulator	-
JQM61_RS24455	5198009..5199358	-	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10458.20 Da
• Isoelectric Point: 10.0435

>T190071 WP_034037564.1 NZ_CP069198:5194328-5194609 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLPLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T190071 NZ_CP091068:4193722-4193940 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT190071 WP_003083775.1 NZ_CP069198:5194104-5194331 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT190071 NZ_CP091068:4193321-4193695 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9