Detailed information of TA system TA190066

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 2897241..2897800
• Replicon: chromosome
• Accession: NZ_CP069195
• Organism: Vibrio diabolicus strain SLV18

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JOS67_RS13805
• Protein ID: WP_203346711.1
• Coordinates: 2897522..2897800 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JOS67_RS13800
• Protein ID: WP_203346710.1
• Coordinates: 2897241..2897525 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JOS67_RS13780	2893064..2893351	-	288	WP_203346708.1	hypothetical protein	-
JOS67_RS13785	2893696..2894109	-	414	WP_203346709.1	hypothetical protein	-
JOS67_RS13790	2894240..2895255	+	1016	Protein_2514	IS110 family transposase	-
JOS67_RS13795	2895574..2897008	-	1435	Protein_2515	IS66 family transposase	-
JOS67_RS13800	2897241..2897525	+	285	WP_203346710.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JOS67_RS13805	2897522..2897800	+	279	WP_203346711.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JOS67_RS13810	2898370..2900016	+	1647	WP_203346712.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	ugd	2859745..2908940	49195

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-74)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10979.70 Da
• Isoelectric Point: 4.2597

>T190066 WP_203346711.1 NZ_CP069195:2897522-2897800 [Vibrio diabolicus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDDIRGRLLIIPEISMIVSYWVDGDIIRIM
RVLHQKQKFPMD

Nucleotide

• Length: 279 bp

>T190066 NZ_CP091068:343872-344240 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11019.38 Da
• Isoelectric Point: 9.2167

>AT190066 WP_203346710.1 NZ_CP069195:2897241-2897525 [Vibrio diabolicus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKLDSGKAVFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT190066 NZ_CP091068:343654-343875 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA