Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1318198..1318757 Replicon chromosome
Accession NZ_CP069195
Organism Vibrio diabolicus strain SLV18

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag JOS67_RS06620 Protein ID WP_005398411.1
Coordinates 1318198..1318476 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag JOS67_RS06625 Protein ID WP_005398409.1
Coordinates 1318473..1318757 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOS67_RS06595 1314189..1314773 + 585 WP_005396929.1 ribosomal protein S5-alanine N-acetyltransferase -
JOS67_RS06600 1314775..1315362 + 588 WP_203347142.1 HD domain-containing protein -
JOS67_RS06605 1315376..1315849 + 474 WP_012841656.1 DUF2947 domain-containing protein -
JOS67_RS06610 1315894..1316856 - 963 WP_012841657.1 integron integrase -
JOS67_RS06615 1317499..1318053 + 555 WP_140073883.1 hypothetical protein -
JOS67_RS06620 1318198..1318476 - 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
JOS67_RS06625 1318473..1318757 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JOS67_RS06630 1318834..1318947 + 114 WP_203347143.1 DUF3265 domain-containing protein -
JOS67_RS06635 1318970..1319341 + 372 WP_025506710.1 hypothetical protein -
JOS67_RS06640 1319369..1319458 + 90 Protein_1126 DUF3265 domain-containing protein -
JOS67_RS06645 1319538..1320371 + 834 WP_005500228.1 AAA family ATPase -
JOS67_RS06650 1320358..1320900 + 543 WP_005500229.1 hypothetical protein -
JOS67_RS06655 1320903..1321616 + 714 WP_005500230.1 hypothetical protein -
JOS67_RS06660 1321640..1321732 + 93 WP_079749157.1 DUF3265 domain-containing protein -
JOS67_RS06665 1321839..1323020 + 1182 WP_086495616.1 helix-hairpin-helix domain-containing protein -
JOS67_RS06670 1323044..1323136 + 93 WP_072617168.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1317499..1344269 26770
- inside Integron - - 1315894..1327434 11540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T190064 WP_005398411.1 NZ_CP069195:c1318476-1318198 [Vibrio diabolicus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T190064 NZ_CP091067:6134268-6134558 [Pseudomonas sp. BC42]
ATGCACACCCCAGTCACCCGCTTCGACGCGGCGGAGTACCTCAAGACCCCTGAAGACATGGTCGCCTACCTCGACGCCTG
CTTCGAGGAAGACACCGGCGACGGCAAGCTGATCCGCGCCGCCCTCAACGATATCGCCCGCGCCCGCGGCATGACCCAGA
TCGCCCGCGATACCGGCCTGGGCCGCGAGAGCCTGTACAAGGCCCTGGGCAGCCAGGGCAATCCCGAGTTCGCAACTATC
ATCAAGGTCATGAAAGCGCTCGGACTCAAGCTCCACGTCAGCCCGGCCTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT190064 WP_005398409.1 NZ_CP069195:c1318757-1318473 [Vibrio diabolicus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT190064 NZ_CP091067:6133962-6134264 [Pseudomonas sp. BC42]
ATGTACGTCTTCGAGCAGACCCTGGAGTTCAGCCGCTGGCTCCTGCACCTGAAGGATCCGCAAGGCAAAACCCGTGTACT
GGCCAGGATCCGCGCCGCCCAACTGGGCCGATTCGGCGACTGCGAAGCACTGGGTGGAGGCGTCTACGAGATGCGCATCC
ATCGTGGTCCCGGCTACCGGGTGTACTTCTCGCGCCGGGGCACGGTGATCTACCTGTTGTTGATCGGCGGTGACAAGAAC
ACCCAGAGACGCGATATCCAACGCGCCAGGCAACTGGCCCACGACCTCAAGAGCGAGGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References