Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 1318198..1318757 | Replicon | chromosome |
| Accession | NZ_CP069195 | ||
| Organism | Vibrio diabolicus strain SLV18 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A347UR22 |
| Locus tag | JOS67_RS06620 | Protein ID | WP_005398411.1 |
| Coordinates | 1318198..1318476 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR21 |
| Locus tag | JOS67_RS06625 | Protein ID | WP_005398409.1 |
| Coordinates | 1318473..1318757 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JOS67_RS06595 | 1314189..1314773 | + | 585 | WP_005396929.1 | ribosomal protein S5-alanine N-acetyltransferase | - |
| JOS67_RS06600 | 1314775..1315362 | + | 588 | WP_203347142.1 | HD domain-containing protein | - |
| JOS67_RS06605 | 1315376..1315849 | + | 474 | WP_012841656.1 | DUF2947 domain-containing protein | - |
| JOS67_RS06610 | 1315894..1316856 | - | 963 | WP_012841657.1 | integron integrase | - |
| JOS67_RS06615 | 1317499..1318053 | + | 555 | WP_140073883.1 | hypothetical protein | - |
| JOS67_RS06620 | 1318198..1318476 | - | 279 | WP_005398411.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| JOS67_RS06625 | 1318473..1318757 | - | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| JOS67_RS06630 | 1318834..1318947 | + | 114 | WP_203347143.1 | DUF3265 domain-containing protein | - |
| JOS67_RS06635 | 1318970..1319341 | + | 372 | WP_025506710.1 | hypothetical protein | - |
| JOS67_RS06640 | 1319369..1319458 | + | 90 | Protein_1126 | DUF3265 domain-containing protein | - |
| JOS67_RS06645 | 1319538..1320371 | + | 834 | WP_005500228.1 | AAA family ATPase | - |
| JOS67_RS06650 | 1320358..1320900 | + | 543 | WP_005500229.1 | hypothetical protein | - |
| JOS67_RS06655 | 1320903..1321616 | + | 714 | WP_005500230.1 | hypothetical protein | - |
| JOS67_RS06660 | 1321640..1321732 | + | 93 | WP_079749157.1 | DUF3265 domain-containing protein | - |
| JOS67_RS06665 | 1321839..1323020 | + | 1182 | WP_086495616.1 | helix-hairpin-helix domain-containing protein | - |
| JOS67_RS06670 | 1323044..1323136 | + | 93 | WP_072617168.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1317499..1344269 | 26770 | |
| - | inside | Integron | - | - | 1315894..1327434 | 11540 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10891.57 Da Isoelectric Point: 4.3430
>T190064 WP_005398411.1 NZ_CP069195:c1318476-1318198 [Vibrio diabolicus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T190064 NZ_CP091067:6134268-6134558 [Pseudomonas sp. BC42]
ATGCACACCCCAGTCACCCGCTTCGACGCGGCGGAGTACCTCAAGACCCCTGAAGACATGGTCGCCTACCTCGACGCCTG
CTTCGAGGAAGACACCGGCGACGGCAAGCTGATCCGCGCCGCCCTCAACGATATCGCCCGCGCCCGCGGCATGACCCAGA
TCGCCCGCGATACCGGCCTGGGCCGCGAGAGCCTGTACAAGGCCCTGGGCAGCCAGGGCAATCCCGAGTTCGCAACTATC
ATCAAGGTCATGAAAGCGCTCGGACTCAAGCTCCACGTCAGCCCGGCCTGA
ATGCACACCCCAGTCACCCGCTTCGACGCGGCGGAGTACCTCAAGACCCCTGAAGACATGGTCGCCTACCTCGACGCCTG
CTTCGAGGAAGACACCGGCGACGGCAAGCTGATCCGCGCCGCCCTCAACGATATCGCCCGCGCCCGCGGCATGACCCAGA
TCGCCCGCGATACCGGCCTGGGCCGCGAGAGCCTGTACAAGGCCCTGGGCAGCCAGGGCAATCCCGAGTTCGCAACTATC
ATCAAGGTCATGAAAGCGCTCGGACTCAAGCTCCACGTCAGCCCGGCCTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11069.40 Da Isoelectric Point: 9.2167
>AT190064 WP_005398409.1 NZ_CP069195:c1318757-1318473 [Vibrio diabolicus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT190064 NZ_CP091067:6133962-6134264 [Pseudomonas sp. BC42]
ATGTACGTCTTCGAGCAGACCCTGGAGTTCAGCCGCTGGCTCCTGCACCTGAAGGATCCGCAAGGCAAAACCCGTGTACT
GGCCAGGATCCGCGCCGCCCAACTGGGCCGATTCGGCGACTGCGAAGCACTGGGTGGAGGCGTCTACGAGATGCGCATCC
ATCGTGGTCCCGGCTACCGGGTGTACTTCTCGCGCCGGGGCACGGTGATCTACCTGTTGTTGATCGGCGGTGACAAGAAC
ACCCAGAGACGCGATATCCAACGCGCCAGGCAACTGGCCCACGACCTCAAGAGCGAGGGTTGA
ATGTACGTCTTCGAGCAGACCCTGGAGTTCAGCCGCTGGCTCCTGCACCTGAAGGATCCGCAAGGCAAAACCCGTGTACT
GGCCAGGATCCGCGCCGCCCAACTGGGCCGATTCGGCGACTGCGAAGCACTGGGTGGAGGCGTCTACGAGATGCGCATCC
ATCGTGGTCCCGGCTACCGGGTGTACTTCTCGCGCCGGGGCACGGTGATCTACCTGTTGTTGATCGGCGGTGACAAGAAC
ACCCAGAGACGCGATATCCAACGCGCCAGGCAACTGGCCCACGACCTCAAGAGCGAGGGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR22 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR21 |