Detailed information of TA system TA190063

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 54841..55349
• Replicon: plasmid pSLV18-213K
• Accession: NZ_CP069194
• Organism: Vibrio diabolicus strain SLV18

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JOS67_RS00225
• Protein ID: WP_203346344.1
• Coordinates: 55089..55349 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: JOS67_RS00220
• Protein ID: WP_203346343.1
• Coordinates: 54841..55092 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JOS67_RS00215	51590..54589	+	3000	WP_203346342.1	hypothetical protein	-
JOS67_RS00220	54841..55092	+	252	WP_203346343.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JOS67_RS00225	55089..55349	+	261	WP_203346344.1	Txe/YoeB family addiction module toxin	Toxin
JOS67_RS00230	55432..56163	-	732	WP_203346345.1	dipeptidase PepE	-
JOS67_RS00235	56176..57417	-	1242	WP_203346270.1	peptidase T	-
JOS67_RS00240	57429..58790	-	1362	WP_203346271.1	C4-dicarboxylate transporter DcuC	-
JOS67_RS00245	58839..59693	-	855	WP_203346272.1	MurR/RpiR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..111069	111069

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10508.01 Da
• Isoelectric Point: 9.8035

>T190063 WP_203346344.1 NZ_CP069194:55089-55349 [Vibrio diabolicus]
MRLIFSTNAWEDYLYWQKTDKKILKRINTLTKDIQREPYDGIGKPEPLKHGLSGYWSRRINDEHRIVYRYHEDAILIAQL
RFHYSP

Nucleotide

• Length: 261 bp

>T190063 NZ_CP091067:6133962-6134264 [Pseudomonas sp. BC42]
ATGTACGTCTTCGAGCAGACCCTGGAGTTCAGCCGCTGGCTCCTGCACCTGAAGGATCCGCAAGGCAAAACCCGTGTACT
GGCCAGGATCCGCGCCGCCCAACTGGGCCGATTCGGCGACTGCGAAGCACTGGGTGGAGGCGTCTACGAGATGCGCATCC
ATCGTGGTCCCGGCTACCGGGTGTACTTCTCGCGCCGGGGCACGGTGATCTACCTGTTGTTGATCGGCGGTGACAAGAAC
ACCCAGAGACGCGATATCCAACGCGCCAGGCAACTGGCCCACGACCTCAAGAGCGAGGGTTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9271.59 Da
• Isoelectric Point: 4.4750

>AT190063 WP_203346343.1 NZ_CP069194:54841-55092 [Vibrio diabolicus]
MDAISYTAARANLASTMEKVCNDHAPVIITRKSEAPVVMMSLEDYEAMQETTYLLRAPANARRLLESIVELESGKGQERE
LLE

Nucleotide

• Length: 252 bp

>AT190063 NZ_CP091067:6134268-6134558 [Pseudomonas sp. BC42]
ATGCACACCCCAGTCACCCGCTTCGACGCGGCGGAGTACCTCAAGACCCCTGAAGACATGGTCGCCTACCTCGACGCCTG
CTTCGAGGAAGACACCGGCGACGGCAAGCTGATCCGCGCCGCCCTCAACGATATCGCCCGCGCCCGCGGCATGACCCAGA
TCGCCCGCGATACCGGCCTGGGCCGCGAGAGCCTGTACAAGGCCCTGGGCAGCCAGGGCAATCCCGAGTTCGCAACTATC
ATCAAGGTCATGAAAGCGCTCGGACTCAAGCTCCACGTCAGCCCGGCCTGA