Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 1759033..1759726 Replicon chromosome
Accession NZ_CP069185
Organism Enterococcus faecalis strain L11

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag JO410_RS08620 Protein ID WP_002395798.1
Coordinates 1759382..1759726 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag JO410_RS08615 Protein ID WP_002364355.1
Coordinates 1759033..1759365 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JO410_RS08565 1754285..1755178 - 894 WP_002369907.1 recombinase RecT -
JO410_RS08570 1755178..1756122 - 945 WP_002389314.1 YqaJ viral recombinase family protein -
JO410_RS08575 1756220..1756447 - 228 WP_002364220.1 hypothetical protein -
JO410_RS08580 1756447..1756770 - 324 WP_002369793.1 hypothetical protein -
JO410_RS08585 1756814..1756999 - 186 WP_002364222.1 hypothetical protein -
JO410_RS08590 1756990..1757184 - 195 WP_002364223.1 hypothetical protein -
JO410_RS08595 1757237..1757419 + 183 WP_002364224.1 YegP family protein -
JO410_RS08600 1757459..1758184 - 726 WP_174092948.1 ORF6C domain-containing protein -
JO410_RS08605 1758223..1758534 - 312 WP_002381719.1 hypothetical protein -
JO410_RS08610 1758545..1758721 - 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
JO410_RS08615 1759033..1759365 + 333 WP_002364355.1 helix-turn-helix domain-containing protein Antitoxin
JO410_RS08620 1759382..1759726 + 345 WP_002395798.1 ImmA/IrrE family metallo-endopeptidase Toxin
JO410_RS08625 1759760..1760488 + 729 WP_002364358.1 ion transporter -
JO410_RS08630 1760585..1761733 + 1149 WP_002364359.1 site-specific integrase -
JO410_RS08635 1761761..1762204 - 444 WP_002384345.1 hypothetical protein -
JO410_RS08640 1762201..1762476 - 276 WP_002356991.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
JO410_RS08645 1762476..1763522 - 1047 WP_002369171.1 type II secretion system F family protein -
JO410_RS08650 1763479..1764447 - 969 WP_002364362.1 Flp pilus assembly complex ATPase component TadA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-81)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13718.69 Da        Isoelectric Point: 6.1363

>T190057 WP_002395798.1 NZ_CP069185:1759382-1759726 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYMELYKIPSFRNKMEAEADH
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLK

Download         Length: 345 bp

>T190057 NZ_CP091066:c2434518-2434411 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGTGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAGCAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12691.16 Da        Isoelectric Point: 4.6307

>AT190057 WP_002364355.1 NZ_CP069185:1759033-1759365 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp

>AT190057 NZ_CP091066:2434334-2434394 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTATTGCCGTAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References