190056

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 445622..446156 Replicon chromosome
Accession NZ_CP069185
Organism Enterococcus faecalis strain L11

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag JO410_RS02295 Protein ID WP_002360769.1
Coordinates 445881..446156 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag JO410_RS02290 Protein ID WP_002369771.1
Coordinates 445622..445888 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JO410_RS02255 441480..442265 + 786 WP_002360778.1 replication-relaxation family protein -
JO410_RS02260 442271..442759 + 489 WP_002415813.1 hypothetical protein -
JO410_RS02265 443351..443617 + 267 WP_002377947.1 hypothetical protein -
JO410_RS02270 443650..444150 + 501 WP_002360775.1 DnaJ domain-containing protein -
JO410_RS02275 444163..444411 + 249 WP_002360773.1 DUF3850 domain-containing protein -
JO410_RS02280 444487..444903 + 417 WP_010710134.1 single-stranded DNA-binding protein -
JO410_RS02285 444927..445511 + 585 WP_002377949.1 thermonuclease family protein -
JO410_RS02290 445622..445888 + 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JO410_RS02295 445881..446156 + 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
JO410_RS02300 446347..447027 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JO410_RS02305 447195..447803 + 609 WP_002361211.1 response regulator transcription factor -
JO410_RS02310 448267..449106 + 840 WP_002367965.1 aldo/keto reductase -
JO410_RS02315 449129..449611 + 483 WP_002397525.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - EF0485 420247..465026 44779
- flank IS/Tn - - 446347..447027 680


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T190056 WP_002360769.1 NZ_CP069185:445881-446156 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

>T190056 NZ_CP091066:c2413683-2413417 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTCTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGC
ATTGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGACTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT190056 WP_002369771.1 NZ_CP069185:445622-445888 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp

>AT190056 NZ_CP091066:c2413934-2413683 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTAGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAATGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAACAACGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGCAAAACTATAATGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References