Detailed information of TA system TA190053

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 335988..337416
• Replicon: chromosome
• Accession: NZ_CP069178
• Organism: Bulleidia sp. zg-1006

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: JOS54_RS01775
• Protein ID: WP_203245364.1
• Coordinates: 336574..337416 (+)
• Length: 281 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: JOS54_RS01770
• Protein ID: WP_203245363.1
• Coordinates: 335988..336581 (+)
• Length: 198 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JOS54_RS01750	332554..334071	+	1518	WP_203245359.1	ATP-binding cassette domain-containing protein	-
JOS54_RS01755	334061..334765	+	705	WP_203245360.1	energy-coupling factor transporter transmembrane protein EcfT	-
JOS54_RS01760	334776..335360	+	585	WP_203245361.1	MptD family putative ECF transporter S component	-
JOS54_RS01765	335550..335795	+	246	WP_203245362.1	hypothetical protein	-
JOS54_RS01770	335988..336581	+	594	WP_203245363.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
JOS54_RS01775	336574..337416	+	843	WP_203245364.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JOS54_RS01780	337837..338361	+	525	WP_203245365.1	PadR family transcriptional regulator	-
JOS54_RS01785	338368..339021	+	654	WP_203245366.1	HEAT repeat domain-containing protein	-
JOS54_RS01790	339005..339469	+	465	WP_203245367.1	hypothetical protein	-
JOS54_RS01795	339526..339924	+	399	Protein_338	zinc-binding dehydrogenase	-
JOS54_RS01800	339948..340187	+	240	WP_203245368.1	hypothetical protein	-
JOS54_RS01805	340528..340896	+	369	WP_203245369.1	DUF3021 family protein	-
JOS54_RS01810	340922..341143	+	222	WP_203245370.1	DUF3784 domain-containing protein	-
JOS54_RS01815	341464..341958	-	495	WP_203245371.1	phosphatase PAP2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-268)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 281 a.a.
• Molecular weight: 32687.76 Da
• Isoelectric Point: 5.5704

>T190053 WP_203245364.1 NZ_CP069178:336574-337416 [Bulleidia sp. zg-1006]
MNKAKLTTLCHKVSKEVGLSFNSVMLYYFLESILKKLAGSKYSERFIFKGDFLLSSVVGIDSRSTVDIDFLLRNMQLSEE
NIVQMLNETLKPEESDDIFYELQSIVPIKEEDQYGGFRANILCKMENIRQIVPLDIATGDVITPHPIDYKYVSSFGEEEI
IIKAYPIETMLAEKIQTIYARGFLNSRSKDYYDLYIIYKLKDKDVNAEILREACRKTFQYRKTEFDIGKIIDLLENLKTN
EAFLKRWQAYSRKNIYAKDITFEEVLDNGIKMVKKIKNED

Nucleotide

• Length: 843 bp

>T190053 NZ_CP091066:c1916125-1915976 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAAATGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGAGCAAGAAAAGAATTCTGAAGAAGACAATTAG

Antitoxin

Protein

• Length: 198 a.a.
• Molecular weight: 23446.88 Da
• Isoelectric Point: 7.3074

>AT190053 WP_203245363.1 NZ_CP069178:335988-336581 [Bulleidia sp. zg-1006]
MNYEDKIEQHLKQSGGIITTAYCKENNIPTIYLSRLSKDGRLLKIKKGIYMTKDGDYDEYYFFQYQYKKAIFSYETALYL
LGQTDKIPWNIDVTVYNGYKFNEKPNGFNIHYVKKSIYDLGVIQKPTMFGNKVKVYSYERTLCDFIAHKEEMDIEVYVKL
IRSYSSYEERDVHSLYDIAMKMGIENKVREVMEVVYE

Nucleotide

• Length: 594 bp

>AT190053 NZ_CP091066:c1916749-1916150 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGACGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA