Detailed information of TA system TA190050

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3561933..3563154
• Replicon: chromosome
• Accession: NZ_CP069177
• Organism: Pseudomonas aeruginosa strain Z154

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IS492_RS16845
• Protein ID: WP_003160088.1
• Coordinates: 3561933..3562511 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IS492_RS16850
• Protein ID: WP_003117666.1
• Coordinates: 3562600..3563154 (-)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IS492_RS16830 (IS492_16815)	3557209..3558486	+	1278	WP_003102743.1	TolC family protein	-
IS492_RS16835 (IS492_16820)	3558476..3560647	+	2172	WP_016851733.1	type I secretion system permease/ATPase	-
IS492_RS16840 (IS492_16825)	3560637..3561824	+	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
IS492_RS16845 (IS492_16830)	3561933..3562511	-	579	WP_003160088.1	HD domain-containing protein	Toxin
IS492_RS16850 (IS492_16835)	3562600..3563154	-	555	WP_003117666.1	helix-turn-helix transcriptional regulator	Antitoxin
IS492_RS16855 (IS492_16840)	3563312..3565507	-	2196	WP_003117665.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
IS492_RS16860 (IS492_16845)	3565512..3565973	-	462	WP_003102736.1	(2Fe-2S)-binding protein	-
IS492_RS16865 (IS492_16850)	3566304..3566627	+	324	WP_003102734.1	multidrug efflux SMR transporter	-
IS492_RS16870 (IS492_16855)	3566640..3567038	+	399	WP_023089053.1	NADH-quinone oxidoreductase subunit A	-
IS492_RS16875 (IS492_16860)	3567035..3567586	-	552	WP_003102727.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-66)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21816.65 Da
• Isoelectric Point: 5.1625

>T190050 WP_003160088.1 NZ_CP069177:c3562511-3561933 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Nucleotide

• Length: 579 bp

>T190050 NZ_CP091066:1490443-1490904 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.67 Da
• Isoelectric Point: 8.5356

>AT190050 WP_003117666.1 NZ_CP069177:c3563154-3562600 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADKALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT190050 NZ_CP091066:1490116-1490430 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA