Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142664..143169 Replicon chromosome
Accession NZ_CP069177
Organism Pseudomonas aeruginosa strain Z154

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag IS492_RS00655 Protein ID WP_003121619.1
Coordinates 142664..142945 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag IS492_RS00660 Protein ID WP_003112628.1
Coordinates 142942..143169 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS492_RS00630 (IS492_00635) 137915..139264 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
IS492_RS00635 (IS492_00640) 139313..139999 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
IS492_RS00640 (IS492_00645) 140100..140834 + 735 WP_003101224.1 GntR family transcriptional regulator -
IS492_RS00645 (IS492_00650) 141014..141424 + 411 WP_003101225.1 aegerolysin family protein -
IS492_RS00650 (IS492_00655) 141456..142364 - 909 WP_003083769.1 LysR family transcriptional regulator -
IS492_RS00655 (IS492_00660) 142664..142945 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
IS492_RS00660 (IS492_00665) 142942..143169 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
IS492_RS00665 (IS492_00670) 143345..143965 - 621 WP_023088714.1 hypothetical protein -
IS492_RS00670 (IS492_00675) 144066..144566 + 501 WP_003101228.1 LEA type 2 family protein -
IS492_RS00675 (IS492_00680) 144639..144980 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
IS492_RS00680 (IS492_00685) 145062..146489 - 1428 WP_003121620.1 GABA permease -
IS492_RS00685 (IS492_00690) 146658..148151 - 1494 WP_031653061.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T190045 WP_003121619.1 NZ_CP069177:c142945-142664 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T190045 NZ_CP091065:4437679-4438029 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT190045 WP_003112628.1 NZ_CP069177:c143169-142942 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT190045 NZ_CP091065:4437434-4437685 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References