190043

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1363..1943 Replicon plasmid pE
Accession NZ_CP069174
Organism Klebsiella pneumoniae strain KPWX136

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag JLH18_RS29620 Protein ID WP_071177730.1
Coordinates 1363..1677 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag JLH18_RS29625 Protein ID WP_000093040.1
Coordinates 1665..1943 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLH18_RS29605 9..539 + 531 WP_071177729.1 hypothetical protein -
JLH18_RS29610 566..745 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
JLH18_RS29615 771..1199 - 429 WP_001140599.1 hypothetical protein -
JLH18_RS29620 1363..1677 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JLH18_RS29625 1665..1943 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
JLH18_RS29630 2277..2483 - 207 Protein_6 TonB family protein -
JLH18_RS29635 2480..2851 - 372 WP_001237044.1 cell envelope integrity protein TolA -
JLH18_RS29640 3125..3370 - 246 WP_032440458.1 hypothetical protein -
JLH18_RS29645 4015..5502 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11970 11970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T190043 WP_071177730.1 NZ_CP069174:c1677-1363 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

>T190043 NZ_CP091065:c3692617-3692510 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT190043 WP_000093040.1 NZ_CP069174:c1943-1665 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp

>AT190043 NZ_CP091065:3692666-3692732 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References