Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 5897..6444 Replicon plasmid pC
Accession NZ_CP069173
Organism Klebsiella pneumoniae strain KPWX136

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag JLH18_RS28935 Protein ID WP_000970007.1
Coordinates 6163..6444 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag JLH18_RS28930 Protein ID WP_000079941.1
Coordinates 5897..6166 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLH18_RS28910 1450..1911 - 462 WP_174843148.1 PilI type IV pilus biogenesis protein -
JLH18_RS28915 1969..2634 - 666 WP_058100831.1 traC -
JLH18_RS28920 2775..3416 - 642 WP_077250484.1 transcription termination factor NusG -
JLH18_RS28925 4119..4991 + 873 WP_000729438.1 incFII family plasmid replication initiator RepA -
JLH18_RS28930 5897..6166 + 270 WP_000079941.1 hypothetical protein Antitoxin
JLH18_RS28935 6163..6444 + 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JLH18_RS28940 6484..7332 + 849 WP_001057996.1 3'-5' exonuclease -
JLH18_RS28945 7449..7922 + 474 WP_001334658.1 hypothetical protein -
JLH18_RS28950 8399..8665 - 267 WP_000955263.1 hypothetical protein -
JLH18_RS28955 8665..8865 - 201 WP_063120186.1 hypothetical protein -
JLH18_RS28960 8883..10397 - 1515 Protein_12 Tn3-like element TnAs1 family transposase -
JLH18_RS28965 10463..11167 + 705 WP_001067855.1 IS6-like element IS26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid fosA3 / dfrA12 / aadA2 / qacE / sul1 / blaNDM-5 / mph(A) - 1..117844 117844


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10892.63 Da        Isoelectric Point: 9.7617

>T190042 WP_000970007.1 NZ_CP069173:6163-6444 [Klebsiella pneumoniae]
MMEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T190042 NZ_CP091065:3269866-3270330 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT190042 WP_000079941.1 NZ_CP069173:5897-6166 [Klebsiella pneumoniae]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT190042 NZ_CP091065:3269531-3269866 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References