Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 345140..345794 Replicon chromosome
Accession NZ_CP069170
Organism Klebsiella pneumoniae strain KPWX136

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag JLH18_RS01700 Protein ID WP_004144731.1
Coordinates 345140..345547 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JLH18_RS01705 Protein ID WP_002916312.1
Coordinates 345528..345794 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLH18_RS01680 341140..342873 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
JLH18_RS01685 342879..343592 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JLH18_RS01690 343615..344511 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JLH18_RS01695 344612..345133 + 522 WP_002916308.1 flavodoxin FldB -
JLH18_RS01700 345140..345547 - 408 WP_004144731.1 protein YgfX Toxin
JLH18_RS01705 345528..345794 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JLH18_RS01710 346040..347023 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JLH18_RS01715 347174..347833 - 660 WP_002916317.1 hemolysin III family protein -
JLH18_RS01720 347997..348308 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
JLH18_RS01725 348358..349086 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JLH18_RS01730 349205..350638 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T190012 WP_004144731.1 NZ_CP069170:c345547-345140 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T190012 NZ_CP091061:2071079-2071181 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT190012 WP_002916312.1 NZ_CP069170:c345794-345528 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT190012 NZ_CP091061:c2071188-2071043 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References