Detailed information of TA system TA190010

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1669935..1671534
• Replicon: chromosome
• Accession: NZ_CP069163
• Organism: Paludibacterium sp. B53371

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JNO51_RS07965
• Protein ID: WP_215782478.1
• Coordinates: 1669935..1671284 (-)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JNO51_RS07970
• Protein ID: WP_215782479.1
• Coordinates: 1671286..1671534 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNO51_RS07945	1665430..1665915	+	486	WP_215782474.1	Spy/CpxP family protein refolding chaperone	-
JNO51_RS07950	1665984..1666448	+	465	WP_215782475.1	hypothetical protein	-
JNO51_RS07955	1666515..1667240	+	726	WP_215782476.1	pyridoxine 5'-phosphate synthase	-
JNO51_RS07960	1667241..1669712	-	2472	WP_215782477.1	EAL domain-containing protein	-
JNO51_RS07965	1669935..1671284	-	1350	WP_215782478.1	HipA domain-containing protein	Toxin
JNO51_RS07970	1671286..1671534	-	249	WP_215782479.1	XRE family transcriptional regulator	Antitoxin
JNO51_RS07975	1671719..1673296	-	1578	WP_215782480.1	murein biosynthesis integral membrane protein MurJ	-
JNO51_RS07980	1673393..1673767	-	375	WP_215782481.1	hypothetical protein	-
JNO51_RS07985	1673836..1674102	-	267	WP_215782482.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (9-110)

Antitoxin

• HigA2-like, helix-turn-helix domain (11-66)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 49234.84 Da
• Isoelectric Point: 8.5241

>T190010 WP_215782478.1 NZ_CP069163:c1671284-1669935 [Paludibacterium sp. B53371]
MPRRGQSCLHVWMNGVLVGRWHFTEASGHRFQYDQSWLDSPLCRPLSLSLPLRPARDAWQGPVVSRFFDSLLPDSPLQRQ
RLRLYFAADSASAFDLLPHVGQDCPGAIQLTRQEAAPTPLSPAQARVLTPREIEGLLSALRFSPMQTGEAGPLAPVTLPG
SHDKTALLWHQGQWHMPQPGLLSTHILKLPLDRHEDCGLLLSGSLENAWLCQRVATAFGVPVPACELVHFGARRALVIER
ADRRWHADQGVWLGVPRNDLCQAQGMSAEMKYQIHGGPSASAMARLMLGSSDASADRLALVRSLLVFWMLCAFDGHARRF
AVDLLPEGRFRLAPPLGVLSAHPLLGHGPGKLSAEQIRPALGLSDQSPPPSWRTLDGEQWLTHARACALPREEIEQLILS
LTAQALPVSARLRKQLPPGFPVAVAEPILQGVVHAARRLRESLPTASAC

Nucleotide

• Length: 1350 bp

>T190010 NZ_CP091061:732159-732644 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATTCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9265.55 Da
• Isoelectric Point: 11.2730

>AT190010 WP_215782479.1 NZ_CP069163:c1671534-1671286 [Paludibacterium sp. B53371]
MPQNIHSPQNLGAELRNWRRARALTQAMAARRIGIAQKAISALENHTAQSSVERLLQVLSALDLELVLRDKQDGSLHRTQ
DW

Nucleotide

• Length: 249 bp

>AT190010 NZ_CP091061:731869-732162 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA