Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4013397..4014208 Replicon chromosome
Accession NZ_CP069159
Organism Citrobacter sp. R56

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag JM656_RS18925 Protein ID WP_203359093.1
Coordinates 4013397..4013777 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag JM656_RS18930 Protein ID WP_203359094.1
Coordinates 4013840..4014208 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JM656_RS18900 4008613..4009422 - 810 WP_203359089.1 HTH-type transcriptional repressor AllR -
JM656_RS18905 4009513..4009995 - 483 WP_203359090.1 ureidoglycolate lyase -
JM656_RS18910 4010212..4011144 + 933 WP_203359091.1 HTH-type transcriptional activator AllS -
JM656_RS18915 4011579..4012433 + 855 WP_203359092.1 GIY-YIG nuclease family protein -
JM656_RS18920 4012715..4012966 + 252 WP_203361329.1 hypothetical protein -
JM656_RS18925 4013397..4013777 - 381 WP_203359093.1 TA system toxin CbtA family protein Toxin
JM656_RS18930 4013840..4014208 - 369 WP_203359094.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JM656_RS18935 4014230..4014451 - 222 WP_203359095.1 DUF987 family protein -
JM656_RS18940 4014461..4014985 - 525 WP_203361330.1 DNA repair protein RadC -
JM656_RS18945 4015001..4015456 - 456 WP_203359096.1 antirestriction protein -
JM656_RS18950 4015556..4015795 - 240 WP_203359097.1 DUF905 domain-containing protein -
JM656_RS18955 4015871..4016338 - 468 WP_203359098.1 hypothetical protein -
JM656_RS18960 4016362..4016802 - 441 WP_203359099.1 hypothetical protein -
JM656_RS18965 4016799..4017038 - 240 WP_203359100.1 hypothetical protein -
JM656_RS18970 4017079..4017780 - 702 WP_203359101.1 WYL domain-containing protein -
JM656_RS18975 4017999..4018820 - 822 WP_203359102.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14114.26 Da        Isoelectric Point: 7.9302

>T190006 WP_203359093.1 NZ_CP069159:c4013777-4013397 [Citrobacter sp. R56]
MQTLPVSPERAARACPSPVEVWQMLLAHLLAQHYGLALNDTPFADNRIIQAHIDAGISLCDAVNFIVEKYELVRTDRPGF
SITEQSPLVTRIDILHARKTTGLLTRNHYKMVTDITGGNKPQEPKR

Download         Length: 381 bp

>T190006 NZ_CP091059:c104121-103651 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13356.31 Da        Isoelectric Point: 6.5884

>AT190006 WP_203359094.1 NZ_CP069159:c4014208-4013840 [Citrobacter sp. R56]
MSQTTPATPAVNHDVTEPWWGLKCNITPCFGARLVQEGNSLHYLVDRGSIIGTFSNADLRHLDQAFPLLLKQLELMLTSG
EIHPRHPHCVTLHAKGLTCDADTLGSCGYLYIAIYPTPVTTA

Download         Length: 369 bp

>AT190006 NZ_CP091059:c104561-104118 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References