Detailed information of TA system TA189992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 3645352..3646004
• Replicon: chromosome
• Accession: NZ_CP069157
• Organism: Morganella morganii strain DSM 30164

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: JL661_RS17420
• Protein ID: WP_081113485.1
• Coordinates: 3645352..3645699 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: A0A447J977
• Locus tag: JL661_RS17425
• Protein ID: WP_062773288.1
• Coordinates: 3645699..3646004 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JL661_RS17390 (JL661_17390)	3640717..3641340	-	624	WP_004236525.1	thiol:disulfide interchange protein DsbA	-
JL661_RS17395 (JL661_17395)	3641359..3642354	-	996	WP_004236526.1	serine/threonine protein kinase	-
JL661_RS17400 (JL661_17400)	3642354..3642623	-	270	WP_004240741.1	YihD family protein	-
JL661_RS18505	3642844..3643416	+	573	Protein_3397	molybdenum cofactor guanylyltransferase MobA	-
JL661_RS18510	3643423..3643941	+	519	WP_225310111.1	molybdopterin-guanine dinucleotide biosynthesis protein MobB	-
JL661_RS17410 (JL661_17410)	3644151..3644452	+	302	Protein_3399	HdeA/HdeB family chaperone	-
JL661_RS17415 (JL661_17415)	3644580..3645101	+	522	WP_049246570.1	isopentenyl-diphosphate Delta-isomerase	-
JL661_RS17420 (JL661_17420)	3645352..3645699	-	348	WP_081113485.1	GNAT family N-acetyltransferase	Toxin
JL661_RS17425 (JL661_17425)	3645699..3646004	-	306	WP_062773288.1	DUF1778 domain-containing protein	Antitoxin
JL661_RS17430 (JL661_17430)	3646136..3647488	-	1353	WP_004236534.1	glutathione-disulfide reductase	-
JL661_RS17435 (JL661_17435)	3647558..3648400	-	843	WP_036417394.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
JL661_RS17440 (JL661_17440)	3648590..3648979	+	390	WP_004236536.1	DUF1090 domain-containing protein	-
JL661_RS17445 (JL661_17445)	3649391..3650383	+	993	WP_049242212.1	inner membrane protein YhjD	-
JL661_RS17450 (JL661_17450)	3650491..3650697	+	207	WP_004236540.1	4-oxalocrotonate tautomerase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (28-90)

Antitoxin

• Vibrio phage ICP1, Orf50 (21-91)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12442.62 Da
• Isoelectric Point: 10.3028

>T189992 WP_081113485.1 NZ_CP069157:c3645699-3645352 [Morganella morganii]
MAYYALSTGVITCSQAAGRFRRNMPPEIPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNA
RRFYEHTGFMPSPADPMLLMITLRDLQLATGIYSE

Nucleotide

• Length: 348 bp

>T189992 NZ_CP091049:58195-58479 [Klebsiella pneumoniae]
ATGACCTATAAGTTAGCCTTCAATGAATCAGCTTTGAAAGAATGGAAAAAACTGGGTCATACTATTCGGGAGCAATTCAA
AAAGAAGCTTTCCGAACGGCTTCAGAACCCACGGGTGCCCGCAGCACAACTCCATGGAGGTAAAGACCAGTATAAAATAA
AGCTCCATGGCGCGGGTTACCGACTGGTTTACAGTGTCAACGATGAAATTGTGACGGTCACCGTAATTGGGGTGGGCAAA
CGCAACAATGATGATATCTACAACGCAACCCGACACAGAAATTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11118.52 Da
• Isoelectric Point: 6.6439

>AT189992 WP_062773288.1 NZ_CP069157:c3646004-3645699 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALHGHLSSATITG

Nucleotide

• Length: 306 bp

>AT189992 NZ_CP091049:57957-58205 [Klebsiella pneumoniae]
ATGGCATTTCAGGTTTTAACCACCACAGCAGCCAGCATTACAGAACTTAAACGTGACCCTATGGGTACCTTCAATGCAGG
AGAAGGTGCACCGGTAGCAATCCTGAATCGCAACGAACCCGCTTTTTACTGTGTACCACCAGCCCTGTATGCTCAGCTGA
TGGAAATGCTGGAAGATCAAGAGTTGGGGCGTATTGCTGATGAACGAATCGGTGAGGACCGAATCGAGGTCAACATTGAT
GACCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A447J977