Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
Location | 2904115..2904698 | Replicon | chromosome |
Accession | NZ_CP069133 | ||
Organism | Escherichia coli BW25113 substr. CHXR2G20 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | S1EZP4 |
Locus tag | JQK31_RS14155 | Protein ID | WP_000254738.1 |
Coordinates | 2904115..2904450 (-) | Length | 112 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | S1P3W5 |
Locus tag | JQK31_RS14160 | Protein ID | WP_000581937.1 |
Coordinates | 2904450..2904698 (-) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JQK31_RS14140 | 2900002..2901300 | - | 1299 | WP_000036723.1 | phosphopyruvate hydratase | - |
JQK31_RS14145 | 2901388..2903025 | - | 1638 | WP_000210878.1 | CTP synthase (glutamine hydrolyzing) | - |
JQK31_RS14150 | 2903253..2904044 | - | 792 | WP_001071648.1 | nucleoside triphosphate pyrophosphohydrolase | - |
JQK31_RS14155 | 2904115..2904450 | - | 336 | WP_000254738.1 | endoribonuclease MazF | Toxin |
JQK31_RS14160 | 2904450..2904698 | - | 249 | WP_000581937.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
JQK31_RS14165 | 2904776..2907010 | - | 2235 | WP_000226815.1 | GTP pyrophosphokinase | - |
JQK31_RS14170 | 2907058..2908359 | - | 1302 | WP_000046812.1 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12098.04 Da Isoelectric Point: 8.2618
>T189975 WP_000254738.1 NZ_CP069133:c2904450-2904115 [Escherichia coli BW25113]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
Download Length: 336 bp
>T189975 NZ_CP091044:4271769-4271921 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9355.74 Da Isoelectric Point: 4.4665
>AT189975 WP_000581937.1 NZ_CP069133:c2904698-2904450 [Escherichia coli BW25113]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
Download Length: 249 bp
>AT189975 NZ_CP091044:c4271720-4271663 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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