189931

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2770470..2771137 Replicon chromosome
Accession NZ_CP069132
Organism Escherichia coli BW25113 substr. CHXR1G20

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag JQK35_RS13505 Protein ID WP_001094400.1
Coordinates 2770808..2771137 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag JQK35_RS13500 Protein ID WP_000072690.1
Coordinates 2770470..2770787 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQK35_RS13470 2765522..2766531 - 1010 Protein_2633 arsenic transporter -
JQK35_RS13475 2766673..2768376 + 1704 WP_000896263.1 hypothetical protein -
JQK35_RS13480 2768948..2769171 + 224 Protein_2635 DUF905 family protein -
JQK35_RS13485 2769274..2769732 + 459 WP_000211841.1 antirestriction protein -
JQK35_RS13490 2769741..2770223 + 483 WP_001407480.1 RadC family protein -
JQK35_RS13495 2770232..2770432 + 201 WP_001395452.1 DUF987 domain-containing protein -
JQK35_RS13500 2770470..2770787 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JQK35_RS13505 2770808..2771137 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
JQK35_RS13510 2771501..2776081 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T189931 WP_001094400.1 NZ_CP069132:2770808-2771137 [Escherichia coli BW25113]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

>T189931 NZ_CP091029:194590-194697 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT189931 WP_000072690.1 NZ_CP069132:2770470-2770787 [Escherichia coli BW25113]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT189931 NZ_CP091029:c194532-194478 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References