189901

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 606132..606768 Replicon chromosome
Accession NZ_CP069098
Organism Bacillus altitudinis strain 63-2-2

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag JNE42_RS03015 Protein ID WP_003214169.1
Coordinates 606418..606768 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag JNE42_RS03010 Protein ID WP_003214273.1
Coordinates 606132..606413 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNE42_RS02990 602287..602892 - 606 WP_203144129.1 rhomboid family intramembrane serine protease -
JNE42_RS02995 602987..603352 + 366 WP_048001253.1 holo-ACP synthase -
JNE42_RS03000 603513..604529 + 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
JNE42_RS03005 604657..605838 + 1182 WP_113767288.1 alanine racemase -
JNE42_RS03010 606132..606413 + 282 WP_003214273.1 hypothetical protein Antitoxin
JNE42_RS03015 606418..606768 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
JNE42_RS03020 606883..607713 + 831 WP_058336383.1 STAS domain-containing protein -
JNE42_RS03025 607718..608086 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
JNE42_RS03030 608089..608490 + 402 WP_003214085.1 anti-sigma regulatory factor -
JNE42_RS03035 608501..609508 + 1008 WP_017358394.1 PP2C family protein-serine/threonine phosphatase -
JNE42_RS03040 609568..609897 + 330 WP_017358393.1 anti-sigma factor antagonist -
JNE42_RS03045 609894..610382 + 489 WP_041507147.1 anti-sigma B factor RsbW -
JNE42_RS03050 610348..611136 + 789 WP_012009000.1 RNA polymerase sigma factor SigB -
JNE42_RS03055 611136..611735 + 600 WP_024719202.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T189901 WP_003214169.1 NZ_CP069098:606418-606768 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T189901 NZ_CP091024:4012984-4013262 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT189901 WP_003214273.1 NZ_CP069098:606132-606413 [Bacillus altitudinis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT189901 NZ_CP091024:4012721-4012981 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References