Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 938414..938946 Replicon chromosome
Accession NZ_CP069082
Organism Staphylococcus gallinarum strain STP534

Toxin (Protein)


Gene name mazF Uniprot ID A0A0D0SFD8
Locus tag JN168_RS04240 Protein ID WP_042739509.1
Coordinates 938584..938946 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0D0QV27
Locus tag JN168_RS04235 Protein ID WP_042739510.1
Coordinates 938414..938587 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN168_RS04210 934244..934723 + 480 WP_279526196.1 PH domain-containing protein -
JN168_RS04215 934716..936221 + 1506 WP_042739514.1 PH domain-containing protein -
JN168_RS04220 936208..936699 + 492 WP_042739513.1 PH domain-containing protein -
JN168_RS04225 936721..937074 + 354 WP_042739512.1 holo-ACP synthase -
JN168_RS04230 937177..938325 + 1149 WP_229366884.1 alanine racemase -
JN168_RS04235 938414..938587 + 174 WP_042739510.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
JN168_RS04240 938584..938946 + 363 WP_042739509.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JN168_RS04245 939320..940321 + 1002 WP_042739508.1 PP2C family protein-serine/threonine phosphatase -
JN168_RS04250 940400..940726 + 327 WP_042739507.1 anti-sigma factor antagonist -
JN168_RS04255 940728..941210 + 483 WP_042739506.1 anti-sigma B factor RsbW -
JN168_RS04260 941185..941955 + 771 WP_042739505.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13612.85 Da        Isoelectric Point: 10.1196

>T189893 WP_042739509.1 NZ_CP069082:938584-938946 [Staphylococcus gallinarum]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEEKMKEVNYAIDISLGLHNVRNHKP

Download         Length: 363 bp

>T189893 NZ_CP091024:1940593-1940847 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6415.09 Da        Isoelectric Point: 4.0121

>AT189893 WP_042739510.1 NZ_CP069082:938414-938587 [Staphylococcus gallinarum]
MVSITQSRNHNSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEIYISSKNNNE

Download         Length: 174 bp

>AT189893 NZ_CP091024:1940345-1940596 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D0SFD8

Antitoxin

Source ID Structure
AlphaFold DB A0A0D0QV27

References