Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 3073246..3074285 | Replicon | chromosome |
| Accession | NZ_CP069080 | ||
| Organism | Pseudomonas putida strain LWPZF | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | JNO42_RS14275 | Protein ID | WP_239608071.1 |
| Coordinates | 3073246..3073821 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A7L5F0B4 |
| Locus tag | JNO42_RS14280 | Protein ID | WP_043156233.1 |
| Coordinates | 3073818..3074285 (-) | Length | 156 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JNO42_RS14250 (JNO42_14150) | 3069686..3070411 | - | 726 | WP_100773617.1 | CBASS effector endonuclease NucC | - |
| JNO42_RS14255 (JNO42_14155) | 3070448..3071350 | - | 903 | WP_100773618.1 | CBASS oligonucleotide cyclase | - |
| JNO42_RS14260 (JNO42_14160) | 3071350..3071850 | - | 501 | WP_100773619.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap7 | - |
| JNO42_RS14265 (JNO42_14165) | 3071847..3072317 | - | 471 | WP_100773620.1 | hypothetical protein | - |
| JNO42_RS14270 (JNO42_14170) | 3072314..3073228 | - | 915 | WP_100773621.1 | AAA family ATPase | - |
| JNO42_RS14275 (JNO42_14175) | 3073246..3073821 | - | 576 | WP_239608071.1 | PIN domain-containing protein | Toxin |
| JNO42_RS14280 (JNO42_14180) | 3073818..3074285 | - | 468 | WP_043156233.1 | helix-turn-helix domain-containing protein | Antitoxin |
| JNO42_RS14285 (JNO42_14185) | 3074499..3074879 | + | 381 | WP_100773623.1 | RAQPRD family integrative conjugative element protein | - |
| JNO42_RS14290 (JNO42_14190) | 3074876..3075109 | + | 234 | WP_003050225.1 | TIGR03758 family integrating conjugative element protein | - |
| JNO42_RS14295 (JNO42_14195) | 3075126..3075485 | + | 360 | WP_100773624.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| JNO42_RS14300 (JNO42_14200) | 3075497..3075895 | + | 399 | WP_100773625.1 | TIGR03750 family conjugal transfer protein | - |
| JNO42_RS14305 (JNO42_14205) | 3075892..3076581 | + | 690 | WP_100773626.1 | TIGR03746 family integrating conjugative element protein | - |
| JNO42_RS14310 (JNO42_14210) | 3076578..3077504 | + | 927 | WP_100773627.1 | TIGR03749 family integrating conjugative element protein | - |
| JNO42_RS14315 (JNO42_14215) | 3077494..3078912 | + | 1419 | WP_100773628.1 | TIGR03752 family integrating conjugative element protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 3031192..3119111 | 87919 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21586.63 Da Isoelectric Point: 5.6513
>T189888 WP_239608071.1 NZ_CP069080:c3073821-3073246 [Pseudomonas putida]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQTIHEEWKRNLLINRLDLTRAQVDRTSDLMDRAIPDGLVEGY
ESLAAGLTLPDPDDRHVLAAAIRCGASVIVTFNQRDFPNELLAPYGVESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLRN
PTIDVDRYLDILLRQGLVQTTKVLAGYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQTIHEEWKRNLLINRLDLTRAQVDRTSDLMDRAIPDGLVEGY
ESLAAGLTLPDPDDRHVLAAAIRCGASVIVTFNQRDFPNELLAPYGVESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLRN
PTIDVDRYLDILLRQGLVQTTKVLAGYRTIL
Download Length: 576 bp
>T189888 NZ_CP091024:c819499-819122 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCCCTAGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCCCTAGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 156 a.a. Molecular weight: 17251.62 Da Isoelectric Point: 5.9214
>AT189888 WP_043156233.1 NZ_CP069080:c3074285-3073818 [Pseudomonas putida]
MTVTAQSKMTLPAEGEVKAAVQGQRALAAYLATQFETQHIQIFDDQKQAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELTQQSQELGMGYE
MTVTAQSKMTLPAEGEVKAAVQGQRALAAYLATQFETQHIQIFDDQKQAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELTQQSQELGMGYE
Download Length: 468 bp
>AT189888 NZ_CP091024:c819957-819589 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATTCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATTCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|