Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2403008..2403891 Replicon chromosome
Accession NZ_CP069080
Organism Pseudomonas putida strain LWPZF

Toxin (Protein)


Gene name - Uniprot ID A0A173HDN1
Locus tag JNO42_RS11180 Protein ID WP_019751987.1
Coordinates 2403008..2403445 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID I7C3Q7
Locus tag JNO42_RS11185 Protein ID WP_003250525.1
Coordinates 2403442..2403891 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNO42_RS11165 (JNO42_11100) 2399310..2400539 - 1230 WP_019751985.1 acyl-CoA dehydrogenase -
JNO42_RS11170 (JNO42_11105) 2400679..2401602 + 924 WP_004573723.1 LysR family transcriptional regulator -
JNO42_RS11175 (JNO42_11110) 2401796..2402950 + 1155 WP_029380674.1 aminotransferase class V-fold PLP-dependent enzyme -
JNO42_RS11180 (JNO42_11115) 2403008..2403445 - 438 WP_019751987.1 RES family NAD+ phosphorylase Toxin
JNO42_RS11185 (JNO42_11120) 2403442..2403891 - 450 WP_003250525.1 DUF2384 domain-containing protein Antitoxin
JNO42_RS11190 (JNO42_11125) 2404034..2404687 - 654 WP_239607857.1 oxygen-insensitive NAD(P)H nitroreductase -
JNO42_RS11195 (JNO42_11130) 2404791..2405714 + 924 WP_239607858.1 LysR family transcriptional regulator -
JNO42_RS11200 (JNO42_11135) 2405763..2406593 + 831 WP_019751988.1 AraC family transcriptional regulator -
JNO42_RS11205 (JNO42_11140) 2406645..2407229 + 585 WP_143493639.1 LysE family transporter -
JNO42_RS11210 (JNO42_11145) 2407269..2408468 - 1200 WP_014861778.1 sugar transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-138)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(33-91)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15953.22 Da        Isoelectric Point: 6.0704

>T189887 WP_019751987.1 NZ_CP069080:c2403445-2403008 [Pseudomonas putida]
VILWRISAYADLSGTGGLRVSGRWHQAGRPVVYAATSPPGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQ
PGWSAHPELTRTLGNRFLDDGSALLLPVPSAIMPSTTNYLFNPRHPQAQSAKIQVEDFTPDSRLF

Download         Length: 438 bp

>T189887 NZ_CP091024:c628583-628119 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16956.46 Da        Isoelectric Point: 5.7258

>AT189887 WP_003250525.1 NZ_CP069080:c2403891-2403442 [Pseudomonas putida]
MLAEVLRDNGYHEYRARLQALLDIPELASDFEIHTRITDGFAATWLVKLTERGVLTPVERDQIIPLRTLKSRIERDQPLT
VDESDRLFRSAHITAMAEAVFGEAGKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGYGL

Download         Length: 450 bp

>AT189887 NZ_CP091024:c628918-628583 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A173HDN1

Antitoxin

Source ID Structure
AlphaFold DB I7C3Q7

References