Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 943459..943945 Replicon chromosome
Accession NZ_CP069079
Organism Streptococcus parasuis strain BS26

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JOA01_RS04830 Protein ID WP_217375106.1
Coordinates 943459..943716 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JOA01_RS04835 Protein ID WP_105142535.1
Coordinates 943706..943945 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA01_RS04800 (JOA01_04805) 938831..939529 + 699 WP_254451660.1 DUF3307 domain-containing protein -
JOA01_RS04805 (JOA01_04810) 939604..939948 + 345 Protein_915 hypothetical protein -
JOA01_RS04810 (JOA01_04815) 940113..941183 + 1071 WP_217375158.1 tyrosine recombinase XerS -
JOA01_RS04815 (JOA01_04820) 941200..941454 - 255 WP_217375104.1 hypothetical protein -
JOA01_RS04820 (JOA01_04825) 941815..942756 - 942 WP_217375105.1 sensor histidine kinase -
JOA01_RS04825 (JOA01_04830) 942753..943421 - 669 WP_172036118.1 response regulator transcription factor -
JOA01_RS04830 (JOA01_04835) 943459..943716 - 258 WP_217375106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JOA01_RS04835 (JOA01_04840) 943706..943945 - 240 WP_105142535.1 DUF6290 family protein Antitoxin
JOA01_RS04840 (JOA01_04845) 944036..946006 - 1971 WP_217375107.1 ABC transporter permease -
JOA01_RS04845 (JOA01_04850) 946008..946760 - 753 WP_217375108.1 ABC transporter ATP-binding protein -
JOA01_RS04850 (JOA01_04855) 946769..947158 - 390 WP_217375109.1 NisI/SpaI family lantibiotic immunity lipoprotein -
JOA01_RS04855 (JOA01_04860) 947171..947311 - 141 WP_172036121.1 hypothetical protein -
JOA01_RS04860 (JOA01_04865) 947450..948616 - 1167 WP_217375110.1 ATP-grasp domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9913.64 Da        Isoelectric Point: 10.6957

>T189884 WP_217375106.1 NZ_CP069079:c943716-943459 [Streptococcus parasuis]
MSYKVILSARVQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGIALTANRSGQWRYRIGNYRVIVSIEDDKLIMTSIKM
RNGSM

Download         Length: 258 bp

>T189884 NZ_CP091024:195555-195662 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8763.02 Da        Isoelectric Point: 3.8548

>AT189884 WP_105142535.1 NZ_CP069079:c943945-943706 [Streptococcus parasuis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLAALEDEYDARVADIAWAEYQADLANGIEPITLEQMAEELGIEL

Download         Length: 240 bp

>AT189884 NZ_CP091024:c195498-195443 [Escherichia coli]
TCAAGATTAGCCCCCGTTATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References