Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3821528..3822213 Replicon chromosome
Accession NZ_CP069078
Organism Mycobacterium tuberculosis strain N0157

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag IMW72_RS17985 Protein ID WP_003417998.1
Coordinates 3821803..3822213 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IMW72_RS17980 Protein ID WP_003912220.1
Coordinates 3821528..3821806 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMW72_RS17960 3817517..3819118 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
IMW72_RS17965 3819135..3819839 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
IMW72_RS17970 3819957..3820523 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
IMW72_RS17975 3820585..3821472 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
IMW72_RS17980 3821528..3821806 + 279 WP_003912220.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IMW72_RS17985 3821803..3822213 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
IMW72_RS17990 3822246..3823982 - 1737 WP_003418002.1 cholesterol oxidase -
IMW72_RS17995 3824038..3825165 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
IMW72_RS18000 3825185..3826774 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T189883 WP_003417998.1 NZ_CP069078:3821803-3822213 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T189883 NZ_CP091024:195072-195179 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.75 Da        Isoelectric Point: 10.1819

>AT189883 WP_003912220.1 NZ_CP069078:3821528-3821806 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Download         Length: 279 bp

>AT189883 NZ_CP091024:c195015-194960 [Escherichia coli]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure

References