Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3701718..3702392 Replicon chromosome
Accession NZ_CP069078
Organism Mycobacterium tuberculosis strain N0157

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag IMW72_RS17525 Protein ID WP_003417282.1
Coordinates 3701718..3702146 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag IMW72_RS17530 Protein ID WP_003417286.1
Coordinates 3702150..3702392 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMW72_RS17500 3697540..3697941 - 402 WP_003417264.1 cytidine deaminase -
IMW72_RS17505 3698178..3698516 + 339 WP_003904248.1 succinate dehydrogenase, cytochrome b556 subunit -
IMW72_RS17510 3698513..3698947 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
IMW72_RS17515 3699076..3700848 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
IMW72_RS17520 3700848..3701639 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
IMW72_RS17525 3701718..3702146 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
IMW72_RS17530 3702150..3702392 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
IMW72_RS17535 3702514..3703128 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
IMW72_RS17540 3703125..3703790 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
IMW72_RS17545 3703791..3704324 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
IMW72_RS17550 3704321..3704695 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T189880 WP_003417282.1 NZ_CP069078:c3702146-3701718 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T189880 NZ_CP069078:c3702146-3701718 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT189880 WP_003417286.1 NZ_CP069078:c3702392-3702150 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT189880 NZ_CP069078:c3702392-3702150 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References