Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3172149..3172697 Replicon chromosome
Accession NZ_CP069078
Organism Mycobacterium tuberculosis strain N0157

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag IMW72_RS15135 Protein ID WP_003414602.1
Coordinates 3172434..3172697 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag IMW72_RS15130 Protein ID WP_003414599.1
Coordinates 3172149..3172430 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMW72_RS15105 3167772..3168629 - 858 WP_003899513.1 type I methionyl aminopeptidase -
IMW72_RS15110 3168671..3169255 - 585 WP_003414585.1 DUF1707 domain-containing protein -
IMW72_RS15115 3169359..3169607 + 249 WP_003913411.1 antitoxin VapB23 -
IMW72_RS15120 3169604..3169984 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
IMW72_RS15125 3170066..3171877 - 1812 WP_003414596.1 penicillin-binding protein -
IMW72_RS15130 3172149..3172430 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
IMW72_RS15135 3172434..3172697 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMW72_RS15140 3173070..3173924 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
IMW72_RS15145 3173980..3175143 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
IMW72_RS15150 3175160..3176374 - 1215 WP_003414610.1 zinc metalloprotease Rip -
IMW72_RS15155 3176382..3177623 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T189877 WP_003414602.1 NZ_CP069078:3172434-3172697 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T189877 NZ_CP091022:4185143-4185484 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCACCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTAATTAC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT189877 WP_003414599.1 NZ_CP069078:3172149-3172430 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT189877 NZ_CP091022:c4185148-4185072 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References