Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2409008..2409537 Replicon chromosome
Accession NZ_CP069078
Organism Mycobacterium tuberculosis strain N0157

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag IMW72_RS11305 Protein ID WP_003411124.1
Coordinates 2409008..2409325 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag IMW72_RS11310 Protein ID WP_003411127.1
Coordinates 2409322..2409537 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMW72_RS11275 2404145..2405221 + 1077 WP_003907870.1 hypothetical protein -
IMW72_RS11280 2405218..2405499 + 282 WP_003411112.1 DUF5703 family protein -
IMW72_RS11285 2405535..2406608 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
IMW72_RS11290 2406613..2407143 - 531 WP_003903767.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
IMW72_RS11295 2407191..2408537 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
IMW72_RS11305 2409008..2409325 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMW72_RS11310 2409322..2409537 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
IMW72_RS11315 2409792..2410850 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
IMW72_RS11320 2410980..2411336 - 357 WP_003411130.1 hypothetical protein -
IMW72_RS11325 2411431..2412213 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
IMW72_RS11330 2412481..2412771 - 291 WP_003900476.1 YggT family protein -
IMW72_RS11335 2412933..2413589 - 657 WP_003411133.1 cell division protein SepF -
IMW72_RS11340 2413655..2414431 - 777 WP_003903768.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T189864 WP_003411124.1 NZ_CP069078:c2409325-2409008 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T189864 NZ_CP091022:934323-934730 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT189864 WP_003411127.1 NZ_CP069078:c2409537-2409322 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT189864 NZ_CP091022:934076-934342 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References