Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2234607..2235505 Replicon chromosome
Accession NZ_CP069078
Organism Mycobacterium tuberculosis strain N0157

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag IMW72_RS10480 Protein ID WP_003410001.1
Coordinates 2234607..2235167 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag IMW72_RS10485 Protein ID WP_003410003.1
Coordinates 2235164..2235505 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMW72_RS10450 2229776..2230429 - 654 WP_003409976.1 cutinase Cfp21 -
IMW72_RS10455 2230544..2230774 + 231 WP_003409980.1 DUF167 domain-containing protein -
IMW72_RS10460 2230859..2231770 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
IMW72_RS10465 2231879..2232478 + 600 WP_003409989.1 L-lysine exporter -
IMW72_RS10470 2232894..2233322 + 429 WP_003409992.1 cellulose-binding protein -
IMW72_RS10475 2233548..2234087 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
IMW72_RS10480 2234607..2235167 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
IMW72_RS10485 2235164..2235505 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
IMW72_RS10490 2235591..2235848 + 258 WP_003410006.1 hypothetical protein -
IMW72_RS10495 2235749..2236084 - 336 WP_003410009.1 dehydrogenase -
IMW72_RS10500 2236173..2236517 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
IMW72_RS10505 2236511..2236759 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
IMW72_RS10510 2236859..2239174 - 2316 WP_003899120.1 cation transporter ATPase CptG -
IMW72_RS10515 2239171..2239443 - 273 WP_003903706.1 DUF1490 family protein -
IMW72_RS10520 2239496..2239852 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T189858 WP_003410001.1 NZ_CP069078:c2235167-2234607 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T189858 NZ_CP091021:26918-27193 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAAGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGACCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT189858 WP_003410003.1 NZ_CP069078:c2235505-2235164 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT189858 NZ_CP091021:26634-26918 [Escherichia coli]
ATGCAAATGAAAAACAATAGTGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGGCTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References