Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1967711..1968171 Replicon chromosome
Accession NZ_CP069078
Organism Mycobacterium tuberculosis strain N0157

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag IMW72_RS09220 Protein ID WP_003898996.1
Coordinates 1967923..1968171 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag IMW72_RS09215 Protein ID WP_003408528.1
Coordinates 1967711..1967923 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMW72_RS09200 1964188..1965375 - 1188 WP_003908744.1 nitrate transporter NarK -
IMW72_RS09205 1965662..1965947 + 286 Protein_1815 DUF1876 domain-containing protein -
IMW72_RS09210 1965961..1967643 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
IMW72_RS09215 1967711..1967923 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IMW72_RS09220 1967923..1968171 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
IMW72_RS09225 1968179..1968916 + 738 WP_003898997.1 hypothetical protein -
IMW72_RS09230 1969010..1970710 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
IMW72_RS09235 1970995..1971396 - 402 WP_003408538.1 hypothetical protein -
IMW72_RS09240 1971386..1971997 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T189853 WP_003898996.1 NZ_CP069078:1967923-1968171 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T189853 NZ_CP091020:3004394-3004501 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT189853 WP_003408528.1 NZ_CP069078:1967711-1967923 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT189853 NZ_CP091020:c3004341-3004280 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References