189834

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 710161..710810 Replicon chromosome
Accession NZ_CP069078
Organism Mycobacterium tuberculosis strain N0157

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag IMW72_RS03250 Protein ID WP_003403236.1
Coordinates 710415..710810 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag IMW72_RS03245 Protein ID WP_003403235.1
Coordinates 710161..710415 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMW72_RS03220 705286..705369 + 84 Protein_639 galactose-1-phosphate uridylyltransferase -
IMW72_RS03225 705388..706470 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
IMW72_RS03230 706467..707558 + 1092 WP_003900977.1 galactokinase -
IMW72_RS03235 707953..709110 + 1158 WP_003903091.1 hypothetical protein -
IMW72_RS03240 709121..710068 + 948 WP_003403232.1 DUF732 domain-containing protein -
IMW72_RS03245 710161..710415 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
IMW72_RS03250 710415..710810 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
IMW72_RS03255 710904..711644 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
IMW72_RS03260 711776..712036 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
IMW72_RS03265 712033..712440 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
IMW72_RS03270 712512..713663 - 1152 WP_003903094.1 FIST N-terminal domain-containing protein -
IMW72_RS03275 713756..715483 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T189834 WP_003403236.1 NZ_CP069078:710415-710810 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T189834 NZ_CP091018:c4545320-4544970 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT189834 WP_003403235.1 NZ_CP069078:710161-710415 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT189834 NZ_CP091018:c4545565-4545314 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC2

References