Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 696994..697637 Replicon chromosome
Accession NZ_CP069078
Organism Mycobacterium tuberculosis strain N0157

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag IMW72_RS03165 Protein ID WP_003403187.1
Coordinates 697236..697637 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag IMW72_RS03160 Protein ID WP_003403184.1
Coordinates 696994..697239 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMW72_RS03125 692274..692804 - 531 WP_003917320.1 two component system sensor kinase HK2 -
IMW72_RS03130 692788..693483 - 696 WP_003918099.1 two-component system response regulator TcrA -
IMW72_RS03135 693606..693917 + 312 WP_003403164.1 hypothetical protein -
IMW72_RS03140 693989..694939 + 951 WP_003907436.1 DUF1259 domain-containing protein -
IMW72_RS03145 695180..695764 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
IMW72_RS03150 695766..696476 + 711 Protein_625 IS607 family element RNA-guided endonuclease TnpB -
IMW72_RS03155 696479..696949 + 471 WP_003898523.1 hypothetical protein -
IMW72_RS03160 696994..697239 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IMW72_RS03165 697236..697637 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
IMW72_RS03170 697628..697807 + 180 Protein_629 hypothetical protein -
IMW72_RS03175 698225..698422 - 198 WP_003403191.1 hypothetical protein -
IMW72_RS03180 698502..699659 - 1158 Protein_631 hypothetical protein -
IMW72_RS03185 699711..699932 - 222 WP_003898525.1 DUF4926 domain-containing protein -
IMW72_RS03190 700074..700679 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T189832 WP_003403187.1 NZ_CP069078:697236-697637 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T189832 NZ_CP091018:3004398-3004505 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT189832 WP_003403184.1 NZ_CP069078:696994-697239 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT189832 NZ_CP091018:c3004345-3004284 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References