Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 690904..691550 Replicon chromosome
Accession NZ_CP069078
Organism Mycobacterium tuberculosis strain N0157

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ88
Locus tag IMW72_RS03110 Protein ID WP_003403137.1
Coordinates 690904..691317 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ89
Locus tag IMW72_RS03115 Protein ID WP_003403139.1
Coordinates 691314..691550 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMW72_RS03090 686987..688537 + 1551 WP_003403119.1 MlaD family protein -
IMW72_RS03095 688589..688981 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 -
IMW72_RS03100 688978..689235 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 -
IMW72_RS03105 689418..690653 - 1236 WP_003403128.1 ATP-binding protein -
IMW72_RS03110 690904..691317 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin Toxin
IMW72_RS03115 691314..691550 - 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 Antitoxin
IMW72_RS03120 691654..692160 - 507 WP_003900973.1 two component system sensor kinase HK1 -
IMW72_RS03125 692274..692804 - 531 WP_003917320.1 two component system sensor kinase HK2 -
IMW72_RS03130 692788..693483 - 696 WP_003918099.1 two-component system response regulator TcrA -
IMW72_RS03135 693606..693917 + 312 WP_003403164.1 hypothetical protein -
IMW72_RS03140 693989..694939 + 951 WP_003907436.1 DUF1259 domain-containing protein -
IMW72_RS03145 695180..695764 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
IMW72_RS03150 695766..696476 + 711 Protein_625 IS607 family element RNA-guided endonuclease TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-126)

Antitoxin

SpoVT-AbrB domain

(3-43)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14786.14 Da        Isoelectric Point: 8.1405

>T189831 WP_003403137.1 NZ_CP069078:c691317-690904 [Mycobacterium tuberculosis]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Download         Length: 414 bp

>T189831 NZ_CP091018:3003862-3003969 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8212.41 Da        Isoelectric Point: 5.0351

>AT189831 WP_003403139.1 NZ_CP069078:c691550-691314 [Mycobacterium tuberculosis]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Download         Length: 237 bp

>AT189831 NZ_CP091018:c3003815-3003749 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ88

Antitoxin

Source ID Structure
AlphaFold DB G0TQ89

References