189828

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 636673..637349 Replicon chromosome
Accession NZ_CP069078
Organism Mycobacterium tuberculosis strain N0157

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag IMW72_RS02870 Protein ID WP_003898500.1
Coordinates 636673..637086 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag IMW72_RS02875 Protein ID WP_003402915.1
Coordinates 637083..637349 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMW72_RS02840 632018..632320 - 303 WP_003402896.1 DUF3349 domain-containing protein -
IMW72_RS02845 632380..632658 - 279 WP_003402901.1 hypothetical protein -
IMW72_RS02850 632655..633908 - 1254 WP_003402904.1 inorganic phosphate transporter -
IMW72_RS02855 634028..634414 - 387 WP_003402907.1 VOC family protein -
IMW72_RS02860 634477..635361 - 885 WP_003903053.1 SDR family oxidoreductase -
IMW72_RS02865 635457..636359 - 903 WP_031654206.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
IMW72_RS02870 636673..637086 - 414 WP_003898500.1 type II toxin-antitoxin system VapC family toxin Toxin
IMW72_RS02875 637083..637349 - 267 WP_003402915.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
IMW72_RS02880 637541..639256 - 1716 WP_003903055.1 fatty-acid--CoA ligase FadD8 -
IMW72_RS02885 639334..640938 + 1605 WP_003903056.1 amidohydrolase -
IMW72_RS02890 640935..641915 + 981 WP_003402923.1 o-succinylbenzoate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T189828 WP_003898500.1 NZ_CP069078:c637086-636673 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

>T189828 NZ_CP091018:2202828-2202931 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT189828 WP_003402915.1 NZ_CP069078:c637349-637083 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp

>AT189828 NZ_CP091018:c2202932-2202698 [Escherichia coli]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References