Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 3075885..3076564 | Replicon | chromosome |
Accession | NZ_CP069077 | ||
Organism | Mycobacterium tuberculosis strain N0072 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P9WF90 |
Locus tag | JN135_RS14570 | Protein ID | WP_003414059.1 |
Coordinates | 3075885..3076301 (-) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TF64 |
Locus tag | JN135_RS14575 | Protein ID | WP_003414061.1 |
Coordinates | 3076298..3076564 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JN135_RS14545 | 3071937..3072839 | - | 903 | WP_003900564.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
JN135_RS14550 | 3072908..3073660 | - | 753 | WP_003899465.1 | FAD-dependent thymidylate synthase | - |
JN135_RS14560 | 3073904..3074179 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
JN135_RS14565 | 3074176..3075798 | - | 1623 | WP_003414057.1 | class I SAM-dependent DNA methyltransferase | - |
JN135_RS14570 | 3075885..3076301 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | Toxin |
JN135_RS14575 | 3076298..3076564 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
JN135_RS14580 | 3076590..3076985 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | - |
JN135_RS14585 | 3076982..3077251 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
JN135_RS14590 | 3077261..3078355 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
JN135_RS14595 | 3078352..3078771 | - | 420 | WP_003414070.1 | winged helix-turn-helix domain-containing protein | - |
JN135_RS14600 | 3078770..3078844 | + | 75 | Protein_2881 | hypothetical protein | - |
JN135_RS14605 | 3078845..3079324 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
JN135_RS14610 | 3079395..3080195 | - | 801 | WP_031680801.1 | thymidylate synthase | - |
JN135_RS14615 | 3080351..3081088 | + | 738 | WP_003414079.1 | dienelactone hydrolase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15773.00 Da Isoelectric Point: 7.1294
>T189811 WP_003414059.1 NZ_CP069077:c3076301-3075885 [Mycobacterium tuberculosis]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
Download Length: 417 bp
>T189811 NZ_CP091016:3004388-3004495 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT189811 WP_003414061.1 NZ_CP069077:c3076564-3076298 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT189811 NZ_CP091016:c3004335-3004274 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|