Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 2885289..2885920 | Replicon | chromosome |
Accession | NZ_CP069077 | ||
Organism | Mycobacterium tuberculosis strain N0072 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQ28 |
Locus tag | JN135_RS13540 | Protein ID | WP_003413174.1 |
Coordinates | 2885543..2885920 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P95006 |
Locus tag | JN135_RS13535 | Protein ID | WP_003413167.1 |
Coordinates | 2885289..2885546 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JN135_RS13505 | 2881203..2881517 | + | 315 | WP_009937839.1 | hypothetical protein | - |
JN135_RS13510 | 2881813..2883024 | + | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
JN135_RS13515 | 2883151..2883810 | + | 660 | WP_003900846.1 | LppA family lipoprotein | - |
JN135_RS13520 | 2883807..2884469 | + | 663 | WP_031698290.1 | LppA family lipoprotein | - |
JN135_RS13525 | 2884466..2884744 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
JN135_RS13530 | 2884837..2885250 | + | 414 | WP_003413164.1 | PIN domain nuclease | - |
JN135_RS13535 | 2885289..2885546 | + | 258 | WP_003413167.1 | CopG family transcriptional regulator | Antitoxin |
JN135_RS13540 | 2885543..2885920 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
JN135_RS13545 | 2885936..2886310 | - | 375 | WP_003413177.1 | hypothetical protein | - |
JN135_RS13550 | 2886410..2886805 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
JN135_RS13555 | 2886802..2887047 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
JN135_RS13560 | 2887458..2887877 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
JN135_RS13565 | 2887889..2888698 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
JN135_RS13570 | 2888695..2889948 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
JN135_RS13575 | 2889941..2890453 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13728.72 Da Isoelectric Point: 4.4687
>T189808 WP_003413174.1 NZ_CP069077:2885543-2885920 [Mycobacterium tuberculosis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
Download Length: 378 bp
>T189808 NZ_CP091016:c2204858-2204664 [Escherichia coli]
ATGCGGTATGAAAAAGTCAAACCATGCCCTTTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
CGCGAAGTGTAACGGATGCGAATCCCGAACCGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGCAATAATAATGGAGGTGTTCATGTATAA
ATGCGGTATGAAAAAGTCAAACCATGCCCTTTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
CGCGAAGTGTAACGGATGCGAATCCCGAACCGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGCAATAATAATGGAGGTGTTCATGTATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9453.63 Da Isoelectric Point: 10.6555
>AT189808 WP_003413167.1 NZ_CP069077:2885289-2885546 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT189808 NZ_CP091016:2204487-2204665 [Escherichia coli]
GATGACAGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GATGACAGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQ28 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829C9W5 |