Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2422151..2422680 Replicon chromosome
Accession NZ_CP069077
Organism Mycobacterium tuberculosis strain N0072

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag JN135_RS11360 Protein ID WP_003411124.1
Coordinates 2422151..2422468 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag JN135_RS11365 Protein ID WP_003411127.1
Coordinates 2422465..2422680 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN135_RS11330 2417346..2418422 + 1077 WP_003904789.1 hypothetical protein -
JN135_RS11335 2418419..2418700 + 282 WP_003411112.1 DUF5703 family protein -
JN135_RS11340 2418736..2419809 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
JN135_RS11345 2419814..2420344 - 531 WP_003904790.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
JN135_RS11350 2420392..2421738 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
JN135_RS11360 2422151..2422468 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN135_RS11365 2422465..2422680 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
JN135_RS11370 2422935..2423993 + 1059 WP_003904791.1 phosphoribosyltransferase family protein -
JN135_RS11375 2424123..2424479 - 357 WP_003411130.1 hypothetical protein -
JN135_RS11380 2424574..2425356 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
JN135_RS11385 2425624..2425914 - 291 WP_003900476.1 YggT family protein -
JN135_RS11390 2426076..2426732 - 657 WP_003411133.1 cell division protein SepF -
JN135_RS11395 2426798..2427574 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T189804 WP_003411124.1 NZ_CP069077:c2422468-2422151 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T189804 NZ_CP091016:1481424-1481822 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT189804 WP_003411127.1 NZ_CP069077:c2422680-2422465 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT189804 NZ_CP091016:1481197-1481424 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References