Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2215550..2216094 | Replicon | chromosome |
| Accession | NZ_CP069077 | ||
| Organism | Mycobacterium tuberculosis strain N0072 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | JN135_RS10350 | Protein ID | WP_003409896.1 |
| Coordinates | 2215550..2215846 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | JN135_RS10355 | Protein ID | WP_003409899.1 |
| Coordinates | 2215843..2216094 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JN135_RS10295 | 2210583..2210933 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| JN135_RS10300 | 2210944..2211846 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| JN135_RS10305 | 2211867..2212058 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| JN135_RS10310 | 2212059..2212355 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| JN135_RS10315 | 2212595..2212810 | + | 216 | WP_003409878.1 | antitoxin | - |
| JN135_RS10320 | 2212807..2213118 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN135_RS10325 | 2213092..2213613 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| JN135_RS10330 | 2213588..2213965 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| JN135_RS10335 | 2214007..2214456 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| JN135_RS10340 | 2214453..2214998 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| JN135_RS10345 | 2214887..2215501 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| JN135_RS10350 | 2215550..2215846 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JN135_RS10355 | 2215843..2216094 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| JN135_RS10360 | 2216081..2216575 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| JN135_RS10365 | 2216735..2217142 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| JN135_RS10370 | 2217146..2217418 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JN135_RS10375 | 2217451..2218671 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| JN135_RS10380 | 2219570..2220367 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T189796 WP_003409896.1 NZ_CP069077:c2215846-2215550 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T189796 NZ_CP091016:272189-272419 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT189796 WP_003409899.1 NZ_CP069077:c2216094-2215843 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT189796 NZ_CP091016:272416-272775 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |