189793

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1973088..1973548 Replicon chromosome
Accession NZ_CP069077
Organism Mycobacterium tuberculosis strain N0072

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag JN135_RS09240 Protein ID WP_003898996.1
Coordinates 1973300..1973548 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JZ84
Locus tag JN135_RS09235 Protein ID WP_003904688.1
Coordinates 1973088..1973300 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN135_RS09220 1969566..1970753 - 1188 WP_003898992.1 nitrate transporter NarK -
JN135_RS09225 1971040..1971324 + 285 WP_003408522.1 DUF1876 domain-containing protein -
JN135_RS09230 1971338..1973020 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
JN135_RS09235 1973088..1973300 + 213 WP_003904688.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN135_RS09240 1973300..1973548 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
JN135_RS09245 1973556..1974293 + 738 WP_003898997.1 hypothetical protein -
JN135_RS09250 1974387..1976087 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
JN135_RS09255 1976372..1976773 - 402 WP_003408538.1 hypothetical protein -
JN135_RS09260 1976763..1977374 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T189793 WP_003898996.1 NZ_CP069077:1973300-1973548 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T189793 NZ_CP091013:2141320-2141685 [Burkholderia cenocepacia]
ATGGTAAAAGCCCTTTTCGACACCAACATCCTGATCGATTATCTGGGCGGCGTGGAATCCGCGCGTGCGGAGCTAGGCCG
CTACGACTATCGCGCAATCAGCATGATCTCGTGGATGGAAGTCCTCGTCGGGGCGTCCGCAAGTGACGAGGCCCCCATCC
GTGCATGGCTCTCGTCGTTCAATGTCATCGCGCTCGACAGCACGGTGGCGAATCGCGCCGTGACGATTCGCAAGGAACGC
CGCATACGTCTGCCCGACGCAATCGTGTGGGCGTCGGCACAAGTGAACGGGCTGTTGCTCGTATCGCGCAACACGAAGGA
CTTTCCCGCCTCCGAGCCCGGCGTTCGCGTGCCATATCAGATCTAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7577.77 Da        Isoelectric Point: 9.3146

>AT189793 WP_003904688.1 NZ_CP069077:1973088-1973300 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRAGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT189793 NZ_CP091013:2141108-2141326 [Burkholderia cenocepacia]
ATGAGCCGGATTCTGGTCGATCTGTCGGATGGCCAACTCGACGAGTTGGCCGTCATCGTCGAGACTCAACACCGTCCCCG
CGCCGCCATCATTCGTGACGCGATCGACGCCTACATTGCCCTGAACAAGCACCGGCTTGCCGACGACGTCTTCGGTCTAT
GGAAAGATCGCACGGTCGACGGGCTCGCCTATCAAGAGGAATTGCGCTCGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A806JZ84

References