189792

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1952185..1952798 Replicon chromosome
Accession NZ_CP069077
Organism Mycobacterium tuberculosis strain N0072

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag JN135_RS09125 Protein ID WP_003408465.1
Coordinates 1952185..1952574 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag JN135_RS09130 Protein ID WP_003408469.1
Coordinates 1952571..1952798 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN135_RS09090 1947814..1948728 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
JN135_RS09095 1948731..1949561 + 831 WP_003408448.1 cyclase family protein -
JN135_RS09100 1949561..1949911 + 351 WP_003898986.1 cupin domain-containing protein -
JN135_RS09105 1949964..1950782 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
JN135_RS09110 1950796..1951575 + 780 WP_003408460.1 IclR family transcriptional regulator -
JN135_RS09120 1952006..1952137 + 132 Protein_1798 IS3 family transposase -
JN135_RS09125 1952185..1952574 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
JN135_RS09130 1952571..1952798 - 228 WP_003408469.1 antitoxin Antitoxin
JN135_RS09135 1953016..1954500 + 1485 WP_003904684.1 biotin carboxylase -
JN135_RS09140 1954497..1955744 + 1248 WP_003408476.1 serine hydrolase -
JN135_RS09145 1955787..1956206 - 420 WP_003904685.1 hypothetical protein -
JN135_RS09150 1956196..1956906 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T189792 WP_003408465.1 NZ_CP069077:c1952574-1952185 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T189792 NZ_CP091013:c1796798-1796385 [Burkholderia cenocepacia]
ATGAGCAGGATTGAGACGGAGAAATCATTCGTCGACAGCAATGTCGTGCTGTATCTGCTGTCCGAGGACGAAACCAAGGC
AAACCGTGCGGAGTCGCTGTTCCTGCGGCGGCCGACCATCAGCGTCCAGGTACTGAACGAAGTCGCCAGTGTGTGCAACC
GCAAATTGCGGATGCCGTGGCGCGAGGTAGGGAAGTTTTTGGAGCCGATCAGGAGTTTGTGCCATGTCGTACCGCTCACC
GTCGATGCGCACGACCTCGCGCGGCGGCTGGCAGAGTGGCATCGCTTGTCCTTCTACGATGCATGCATCGTGGCAACTGC
CTCAATCGAAGGATGTGAATACCTGTACACCGAAGACATGCACGACGGCTTGCAAGTGGACGGCGGTCCGGTATTGCGAA
ATCCGTTTGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT189792 WP_003408469.1 NZ_CP069077:c1952798-1952571 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT189792 NZ_CP091013:c1797018-1796785 [Burkholderia cenocepacia]
ATGCAGGTCGCAAAATGGGGCAATAGCCTGGCGGTTCGCCTTCCGGCCAGTGTGGTTGACGCACTGGAACTCCGCGAAGG
CGACGATATTGAGATAGTGGTCGACAGCCCGCGGGTTTTCGCGGTAAGTCGCAAGCCGAGGCCCGACGAGCTTCTGGAGC
GACTGCGGCGTTTCAGGGGCAAATTGCCCGCCGATTTCAAGTTCAGCCGGGACGATGCGAATGAGCAGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References