Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 1691377..1691993 | Replicon | chromosome |
Accession | NZ_CP069077 | ||
Organism | Mycobacterium tuberculosis strain N0072 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | G0TJ74 |
Locus tag | JN135_RS07960 | Protein ID | WP_003407593.1 |
Coordinates | 1691676..1691993 (+) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | G0TJ73 |
Locus tag | JN135_RS07955 | Protein ID | WP_003900349.1 |
Coordinates | 1691377..1691679 (+) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JN135_RS07945 | 1687263..1689110 | + | 1848 | WP_003407585.1 | methylmalonyl-CoA mutase small subunit | - |
JN135_RS07950 | 1689111..1691363 | + | 2253 | WP_003407587.1 | methylmalonyl-CoA mutase | - |
JN135_RS07955 | 1691377..1691679 | + | 303 | WP_003900349.1 | type II toxin-antitoxin system antitoxin MazE4 | Antitoxin |
JN135_RS07960 | 1691676..1691993 | + | 318 | WP_003407593.1 | type II toxin-antitoxin system toxin endoribonuclease MazF4 | Toxin |
JN135_RS07965 | 1691990..1692994 | + | 1005 | WP_003407596.1 | methylmalonyl Co-A mutase-associated GTPase MeaB | - |
JN135_RS07970 | 1693047..1694336 | + | 1290 | WP_003407599.1 | serine hydrolase domain-containing protein | - |
JN135_RS07975 | 1694409..1695026 | - | 618 | WP_003407606.1 | class I SAM-dependent methyltransferase | - |
JN135_RS07980 | 1695240..1695452 | - | 213 | WP_003898900.1 | dodecin family protein | - |
JN135_RS07985 | 1695513..1695911 | + | 399 | WP_003900351.1 | hypothetical protein | - |
JN135_RS07990 | 1695956..1696984 | + | 1029 | WP_003903478.1 | glycosyltransferase family 2 protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 11377.97 Da Isoelectric Point: 7.9950
>T189790 WP_003407593.1 NZ_CP069077:1691676-1691993 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP
Download Length: 318 bp
>T189790 NZ_CP091013:c1076641-1076381 [Burkholderia cenocepacia]
ATGCGCACGATTCATTTTTCCGATGCCCGCGGCAATCTGAAGACCGTCATCGACCAGGTCGTCGACGATGCGGACGTGAC
GCTCATTACGCGCCGCGATGCACCGAACGCCGTCATCATGTCGCAGGACTATTACGACAGCCTGATGGAGACGGTTCACC
TGCTGCGCTCGCCAGCCAACGTCGCTCATCTCGAACGTTCGATCGCGCAACTGCGCAAGGGCAAAGCGAAAGAACACAAG
CTCGCCGAGGACGATGAATGA
ATGCGCACGATTCATTTTTCCGATGCCCGCGGCAATCTGAAGACCGTCATCGACCAGGTCGTCGACGATGCGGACGTGAC
GCTCATTACGCGCCGCGATGCACCGAACGCCGTCATCATGTCGCAGGACTATTACGACAGCCTGATGGAGACGGTTCACC
TGCTGCGCTCGCCAGCCAACGTCGCTCATCTCGAACGTTCGATCGCGCAACTGCGCAAGGGCAAAGCGAAAGAACACAAG
CTCGCCGAGGACGATGAATGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11173.42 Da Isoelectric Point: 9.5564
>AT189790 WP_003900349.1 NZ_CP069077:1691377-1691679 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ
Download Length: 303 bp
>AT189790 NZ_CP091013:c1076384-1076118 [Burkholderia cenocepacia]
ATGAGCGTACGTCGCGTGCTCTTTACTTCCGACGCATGGGATGACTATGTCTACTGGCAAGGACAGGATCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAACCCAGCGCACGCCGTTCGAAGGCATCGGCAAGCCGGAGCCGTTGAAAGCCA
ATCTCTCCGGCTTCTGGTCGCGCCGTATCGACGATACGAACCGCCTGGTCTACGAGGCTGACGACCTTCAAATCAGCATC
GTGTCCTGCCGCTACCATTACGAGTAG
ATGAGCGTACGTCGCGTGCTCTTTACTTCCGACGCATGGGATGACTATGTCTACTGGCAAGGACAGGATCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAACCCAGCGCACGCCGTTCGAAGGCATCGGCAAGCCGGAGCCGTTGAAAGCCA
ATCTCTCCGGCTTCTGGTCGCGCCGTATCGACGATACGAACCGCCTGGTCTACGAGGCTGACGACCTTCAAATCAGCATC
GTGTCCTGCCGCTACCATTACGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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