Detailed information of TA system TA189788

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PhRel-ATphRel/-
• Location: 1544409..1545459
• Replicon: chromosome
• Accession: NZ_CP069077
• Organism: Mycobacterium tuberculosis strain N0072

Toxin (Protein)

• Gene name: phRel
• Uniprot ID: G0TIH2
• Locus tag: JN135_RS07300
• Protein ID: WP_003407164.1
• Coordinates: 1544409..1545230 (+)
• Length: 274 a.a.

Antitoxin (Protein)

• Gene name: ATphRel
• Uniprot ID: A0A7U4BTV8
• Locus tag: JN135_RS07305
• Protein ID: WP_003407167.1
• Coordinates: 1545223..1545459 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN135_RS07280	1539967..1540629	-	663	WP_003407152.1	membrane protein	-
JN135_RS07285	1540626..1541411	-	786	WP_003407157.1	membrane protein	-
JN135_RS07290	1541702..1543663	-	1962	WP_003407159.1	sigma-F factor regulator	-
JN135_RS07295	1543802..1544188	-	387	WP_003904611.1	anti-sigma-F factor antagonist RsfA	-
JN135_RS07300	1544409..1545230	+	822	WP_003407164.1	GTP pyrophosphokinase family protein	Toxin
JN135_RS07305	1545223..1545459	+	237	WP_003407167.1	hypothetical protein	Antitoxin
JN135_RS07310	1545531..1546736	-	1206	WP_003918234.1	serine hydrolase domain-containing protein	-
JN135_RS07315	1547039..1547824	+	786	WP_003407180.1	lipoprotein LprF	-
JN135_RS07320	1548020..1549489	+	1470	WP_003900326.1	cytochrome b5 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (76-174)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 274 a.a.
• Molecular weight: 30100.10 Da
• Isoelectric Point: 5.8187

>T189788 WP_003407164.1 NZ_CP069077:1544409-1545230 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Nucleotide

• Length: 822 bp

>T189788 NZ_CP091013:c999020-998439 [Burkholderia cenocepacia]
ATGAACCCCGATACGATCCACGCGCGACTCGCGTTCCTGCGCGAGGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
TACGTCGGCCGGCCGTCCGGAAAGCACGGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGACGCAC
TGCCCGGCGTCGATACGCTGAAGCTGCTGAAACTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCATCCCGACAAGAGCGCACATGAACGCGACGACCTGCTAATGCTGACCGCGTCGCTCGACCG
CGCGGTACGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGGCGGCCGCATCGCCCGAAGCCCGCGCGGCGAAGGCAC
TCGACAAGCTCGAAACGATCGTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTATGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGACGCTGCGCCGCTGTTCCGCGCGATCCGCGAAATCGTCGACGCCGATACGCAGCGCAAGATCGA
CGCGGGTGGACACCACGCGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8830.90 Da
• Isoelectric Point: 7.3178

>AT189788 WP_003407167.1 NZ_CP069077:1545223-1545459 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Nucleotide

• Length: 237 bp

>AT189788 NZ_CP091013:c999665-999099 [Burkholderia cenocepacia]
ATGCCCCATCCGCCGCTTCATCGATCCTCGCTCGGCCCGCAACTCAAGCGCTGGCGCGCGCTGCACCGCGTGAAGCAAAG
CCATGCAGCCGAACTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCCTCCAGCAGATGTCGCCCGCCG
AGCGCGCGACGGCTGAACGGCTGCTCGCCGCTCGCCTCGATTCCGCGGGCGATCACGCACTCGCGCGGCTGATCGCCGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTGGCCAGTTCACCGGCGCGCGCGGCCGAGTTCTC
GCAACCGCTTTCGACGTTGCTCGGCACGTCGCTGTGGCGCTACGCGACACCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ATCCGCTCGGCTGGCACGACCGCGCGGGGCCGCCGAGCGTCGAGTTCGACACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATTCGCGGCAGCCGATGCCGGTGGACACGGATGACGCTGTCGGACGGCTCGGCCGCGCGGCTCGTGGAAACCCTCGACGC
ACACTGA

Structures

Toxin

• AlphaFold DB: G0TIH2

Antitoxin

• AlphaFold DB: A0A7U4BTV8