Detailed information of TA system TA189787

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1390380..1390939
• Replicon: chromosome
• Accession: NZ_CP069077
• Organism: Mycobacterium tuberculosis strain N0072

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: JN135_RS06630
• Protein ID: WP_003898789.1
• Coordinates: 1390380..1390673 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: JN135_RS06635
• Protein ID: WP_003406322.1
• Coordinates: 1390670..1390939 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN135_RS06605	1385975..1386235	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
JN135_RS06610	1386232..1386663	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
JN135_RS06615	1386686..1388372	-	1687	Protein_1307	PE family protein	-
JN135_RS06620	1388552..1389412	+	861	WP_003903377.1	glycine betaine ABC transporter substrate-binding protein	-
JN135_RS06625	1389493..1390323	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
JN135_RS06630	1390380..1390673	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
JN135_RS06635	1390670..1390939	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JN135_RS06640	1391052..1394747	-	3696	WP_015631286.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
JN135_RS06645	1394889..1395677	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T189787 WP_003898789.1 NZ_CP069077:c1390673-1390380 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T189787 NZ_CP091013:c562592-562221 [Burkholderia cenocepacia]
ATGATCCTTGTCGACACGTCCGTCTGGATCGATCACTTGCGAGCCGGCGACGCGACGCTCACCGCATTGCTGGAAGCGGA
GCGAGTATTGATCCATCCGTTCATCGTCGGCGAGCTTGCGCTCGGCAGCATGCGCAATCGCGAGACCGTGCTAGATGCGC
TGCGCGACCTTCCAGCTGCAACCCTTGCCACCGACGACGAAGTCCAGCGCATGATCGATGCCGTACCGCTTCACGGGCTG
GGCATCGGCTACGTCGATGCCCACCTGCTTGCGTCGGCCAGACTGACCAGCGACAGCAGGCTATGGACGCGCGACCGGCG
CCTGCTGGCGGCAGCGGAGCGCCTGCAACTCGTCGCCCGCCCCGCTCACTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT189787 WP_003406322.1 NZ_CP069077:c1390939-1390670 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT189787 NZ_CP091013:c562786-562589 [Burkholderia cenocepacia]
ATGCGCACCACCTTGTCCCTCGACGACGCACTGCTCGCCAAAGCGCAGCAATTGACCGGCGTCACCGAAAAATCGGCGCT
CGTGAGGGAAGCGCTGCGCGCATTGATCGCCCGCGAAAGTGCGCGACGACTCGCCCGCCTCGGCGGCACCGAGCCTGATC
TTGAATCGGTCCCACGCCGCCCGTCGAAGCCCGCATGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2