Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 719938..720587 Replicon chromosome
Accession NZ_CP069077
Organism Mycobacterium tuberculosis strain N0072

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag JN135_RS03280 Protein ID WP_003403236.1
Coordinates 720192..720587 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag JN135_RS03275 Protein ID WP_003403235.1
Coordinates 719938..720192 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN135_RS03250 715063..715146 + 84 Protein_645 galactose-1-phosphate uridylyltransferase -
JN135_RS03255 715165..716247 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
JN135_RS03260 716244..717335 + 1092 WP_003900977.1 galactokinase -
JN135_RS03265 717730..718887 + 1158 WP_003903091.1 hypothetical protein -
JN135_RS03270 718898..719845 + 948 WP_003403232.1 DUF732 domain-containing protein -
JN135_RS03275 719938..720192 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
JN135_RS03280 720192..720587 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
JN135_RS03285 720681..721421 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
JN135_RS03290 721553..721813 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN135_RS03295 721810..722217 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
JN135_RS03300 722289..723440 - 1152 WP_244736125.1 FIST N-terminal domain-containing protein -
JN135_RS03305 723533..725254 - 1722 WP_244736133.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T189774 WP_003403236.1 NZ_CP069077:720192-720587 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T189774 NZ_CP090994:c27721-27455 [Staphylococcus epidermidis]
ATGAATAAGTACAATATAACTTTCACACCTACAGCTTTTGAAGATTATAAGTATTGGCAAACACAAGATAAAAAACTATT
AAAGAAAATTAATAGTTTGATTAAGAGTATTCAAAGAGATGGCATTTTAGAGGGTGAAGGCAAGGCCGAGCCTTTGAAAG
GTAATTTGAAAGGTTACTATAGTAGAAGAATAAATCACGAGCATAGATTAGTTTATACTATTAAAGACCCTAGTATTATA
ATCATTGCATGTAGATATCATTATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT189774 WP_003403235.1 NZ_CP069077:719938-720192 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT189774 NZ_CP090994:c27968-27714 [Staphylococcus epidermidis]
ATGACTGTTTTAACTTATTCAAACGCACGTAAGGATTTCCGAAAACTAATAGATAAAGTAAATGATGATAGTGATACAGT
AACTATTACAACTAATGACCGTAACGCTGTATTGATTAGTGAAGATGATTATAACTCAATTATGGAAACTCTCTACTTAC
AACAATCACCAGTCAATGCTAAACGCTTAGCTCAATCAATGGAAGAAGCTGAAAGAGTCAATACTGTAGAGGTAGATATA
ACAACTTATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References