Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 714309..714934 Replicon chromosome
Accession NZ_CP069077
Organism Mycobacterium tuberculosis strain N0072

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag JN135_RS03245 Protein ID WP_003403218.1
Coordinates 714533..714934 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag JN135_RS03240 Protein ID WP_003403213.1
Coordinates 714309..714536 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN135_RS03215 709488..709709 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JN135_RS03220 709851..710456 + 606 WP_003898526.1 hypothetical protein -
JN135_RS03225 710475..713042 - 2568 WP_031656768.1 SEC-C metal-binding domain-containing protein -
JN135_RS03230 713126..713875 + 750 WP_003898528.1 hypothetical protein -
JN135_RS03235 713872..714114 + 243 WP_003403210.1 hypothetical protein -
JN135_RS03240 714309..714536 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
JN135_RS03245 714533..714934 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
JN135_RS03250 715063..715146 + 84 Protein_645 galactose-1-phosphate uridylyltransferase -
JN135_RS03255 715165..716247 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
JN135_RS03260 716244..717335 + 1092 WP_003900977.1 galactokinase -
JN135_RS03265 717730..718887 + 1158 WP_003903091.1 hypothetical protein -
JN135_RS03270 718898..719845 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T189773 WP_003403218.1 NZ_CP069077:714533-714934 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T189773 NZ_CP090994:23705-23971 [Staphylococcus epidermidis]
ATGGCTAAATATAAAATCAACATTAAGAATTCAGCGAAGACAGATTTAAAGAAGATAAAACGTTCTCACTTACAAGAACA
ATTTTTGAAAATCGTAGAAATACTAAAATATAATCCATATCAACAAAGTCAATCCTTTGAAAAATTGCACCCTAAACATT
TAGGACGATACTCAAGACGTATCAATCATCAACATAGAGTTGTCTATACAATTGATGAGGAAAATAAAGAAGTATTAATA
TTAGCAACTTGGTCTCATTATGAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT189773 WP_003403213.1 NZ_CP069077:714309-714536 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT189773 NZ_CP090994:23448-23705 [Staphylococcus epidermidis]
ATGAAAAGTAAAACACCAACAGAAGCTCGTAAAGATTTTTATCAGTTATTAAAACGTGTGAATAATGACCATGAACCAGT
ATATATTGAAGGCAAATATGATGAGAGTAATGCTGTTATTATAGGCATGGAAGATTGGCGTAGCATTAATGAAACGATAT
ATCTTGAGGCTACAGGCACAATGGACAAAGTTAGAGAACGTGAGCATGACAACAGTGGTTATACAAACATAGATGATATT
GATTGGGCTAGACTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References