Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 706771..707414 Replicon chromosome
Accession NZ_CP069077
Organism Mycobacterium tuberculosis strain N0072

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag JN135_RS03195 Protein ID WP_003403187.1
Coordinates 707013..707414 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag JN135_RS03190 Protein ID WP_003403184.1
Coordinates 706771..707016 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN135_RS03155 702051..702581 - 531 WP_003917320.1 two component system sensor kinase HK2 -
JN135_RS03160 702565..703260 - 696 WP_200861092.1 two-component system response regulator TcrA -
JN135_RS03165 703383..703694 + 312 WP_003403164.1 hypothetical protein -
JN135_RS03170 703766..704716 + 951 WP_003907436.1 DUF1259 domain-containing protein -
JN135_RS03175 704957..705541 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
JN135_RS03180 705543..706253 + 711 Protein_631 IS607 family element RNA-guided endonuclease TnpB -
JN135_RS03185 706256..706726 + 471 WP_003898523.1 hypothetical protein -
JN135_RS03190 706771..707016 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN135_RS03195 707013..707414 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
JN135_RS03200 707405..707584 + 180 Protein_635 hypothetical protein -
JN135_RS03205 708002..708199 - 198 WP_003403191.1 hypothetical protein -
JN135_RS03210 708279..709436 - 1158 Protein_637 hypothetical protein -
JN135_RS03215 709488..709709 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JN135_RS03220 709851..710456 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T189772 WP_003403187.1 NZ_CP069077:707013-707414 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T189772 NZ_CP090993:1959291-1959479 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATTGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT189772 WP_003403184.1 NZ_CP069077:706771-707016 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT189772 NZ_CP090993:1959009-1959266 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAATTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References