189768

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 643727..644403 Replicon chromosome
Accession NZ_CP069077
Organism Mycobacterium tuberculosis strain N0072

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag JN135_RS02890 Protein ID WP_003898500.1
Coordinates 643727..644140 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag JN135_RS02895 Protein ID WP_003402915.1
Coordinates 644137..644403 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN135_RS02860 639072..639374 - 303 WP_003402896.1 DUF3349 domain-containing protein -
JN135_RS02865 639434..639712 - 279 WP_003402901.1 hypothetical protein -
JN135_RS02870 639709..640962 - 1254 WP_244736122.1 inorganic phosphate transporter -
JN135_RS02875 641082..641468 - 387 WP_003402907.1 VOC family protein -
JN135_RS02880 641531..642415 - 885 WP_003402909.1 SDR family oxidoreductase -
JN135_RS02885 642511..643413 - 903 WP_003915439.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
JN135_RS02890 643727..644140 - 414 WP_003898500.1 type II toxin-antitoxin system VapC family toxin Toxin
JN135_RS02895 644137..644403 - 267 WP_003402915.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JN135_RS02900 644595..646310 - 1716 WP_003402917.1 fatty-acid--CoA ligase FadD8 -
JN135_RS02905 646388..647992 + 1605 WP_003903056.1 amidohydrolase -
JN135_RS02910 647989..648969 + 981 WP_003402923.1 o-succinylbenzoate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T189768 WP_003898500.1 NZ_CP069077:c644140-643727 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

>T189768 NZ_CP090989:2005110-2005298 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT189768 WP_003402915.1 NZ_CP069077:c644403-644137 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp

>AT189768 NZ_CP090989:2004828-2005085 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAATTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References