Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3757151..3757680 Replicon chromosome
Accession NZ_CP069076
Organism Mycobacterium tuberculosis strain N0031

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag JN136_RS17660 Protein ID WP_003417760.1
Coordinates 3757423..3757680 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag JN136_RS17655 Protein ID WP_003417757.1
Coordinates 3757151..3757426 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN136_RS17620 3753724..3754413 - 690 WP_003917774.1 BBE domain-containing protein -
JN136_RS17625 3754600..3754971 - 372 WP_003417739.1 FAD-binding protein -
JN136_RS17630 3754869..3755087 - 219 WP_157132559.1 hypothetical protein -
JN136_RS17635 3755114..3755374 - 261 WP_003417741.1 hypothetical protein -
JN136_RS17640 3755489..3755878 + 390 WP_003417745.1 DUF732 domain-containing protein -
JN136_RS17645 3755892..3756185 - 294 WP_003417749.1 DUF3017 domain-containing protein -
JN136_RS17650 3756182..3757027 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
JN136_RS17655 3757151..3757426 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
JN136_RS17660 3757423..3757680 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
JN136_RS17665 3757722..3758912 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
JN136_RS17670 3759029..3759397 + 369 WP_003417765.1 FHA domain-containing protein -
JN136_RS17675 3759394..3759945 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
JN136_RS17680 3759952..3760533 - 582 WP_003417769.1 ATP/GTP-binding protein -
JN136_RS17685 3760514..3760882 - 369 WP_003417772.1 DUF742 domain-containing protein -
JN136_RS17690 3760860..3761252 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T189760 WP_003417760.1 NZ_CP069076:3757423-3757680 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T189760 NZ_CP090985:c1476831-1476652 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT189760 WP_003417757.1 NZ_CP069076:3757151-3757426 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT189760 NZ_CP090985:c1477454-1476855 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAATTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTATC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References