Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3692743..3693417 Replicon chromosome
Accession NZ_CP069076
Organism Mycobacterium tuberculosis strain N0031

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag JN136_RS17460 Protein ID WP_003417282.1
Coordinates 3692743..3693171 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag JN136_RS17465 Protein ID WP_003417286.1
Coordinates 3693175..3693417 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN136_RS17435 3688565..3688966 - 402 WP_003417264.1 cytidine deaminase -
JN136_RS17440 3689203..3689541 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
JN136_RS17445 3689538..3689972 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
JN136_RS17450 3690101..3691873 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
JN136_RS17455 3691873..3692664 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
JN136_RS17460 3692743..3693171 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
JN136_RS17465 3693175..3693417 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
JN136_RS17470 3693539..3694153 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
JN136_RS17475 3694150..3694815 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
JN136_RS17480 3694816..3695349 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
JN136_RS17485 3695346..3695474 - 129 Protein_3455 4a-hydroxytetrahydrobiopterin dehydratase -
JN136_RS17490 3695523..3696784 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T189759 WP_003417282.1 NZ_CP069076:c3693171-3692743 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T189759 NZ_CP090985:c478821-478633 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT189759 WP_003417286.1 NZ_CP069076:c3693417-3693175 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT189759 NZ_CP090985:c479103-478846 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAATTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References