Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3172179..3172866 Replicon chromosome
Accession NZ_CP069076
Organism Mycobacterium tuberculosis strain N0031

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag JN136_RS15125 Protein ID WP_003414624.1
Coordinates 3172423..3172866 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag JN136_RS15120 Protein ID WP_003414620.1
Coordinates 3172179..3172436 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN136_RS15100 3167499..3168353 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
JN136_RS15105 3168409..3169572 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
JN136_RS15110 3169589..3170803 - 1215 WP_003414610.1 zinc metalloprotease Rip -
JN136_RS15115 3170811..3172052 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
JN136_RS15120 3172179..3172436 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
JN136_RS15125 3172423..3172866 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
JN136_RS15130 3172946..3173608 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
JN136_RS15135 3173704..3173895 + 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
JN136_RS15140 3174227..3175975 + 1749 WP_192933783.1 cytochrome c biogenesis protein DipZ -
JN136_RS15145 3176071..3176652 + 582 WP_003414644.1 fasciclin domain-containing protein -
JN136_RS15150 3176752..3177018 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T189757 WP_003414624.1 NZ_CP069076:3172423-3172866 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T189757 NZ_CP090978:c2685021-2684698 [Paenibacillus sp. YPD9-1]
ATGAGTGCAGATCGAGGAGATCTAGTATGGATAAACTTTAACCCCCAAGCAGGTCACGAACAATCCGGTAGAAGATCTGC
AATCGTGCTCTCACCAAAAGCGTTTAATGAAACGACGGGATTTGTATCTGTTTGCCCAATCACTCATACAGTCCGAGGTT
GGGGGTATGAAGTATTGCTCCCCAATGGGTTGGTGTTTAACGGGGTCATTTTAACGGATCAGATCAAAAATCTTGATTGG
CGAGCTAGGCGAGTGGATATTGTCGGACAAGCTCCGGATGAAGTTGTCAATGAGTGTTTAGACAAAATACACACATTTTT
GTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT189757 WP_003414620.1 NZ_CP069076:3172179-3172436 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT189757 NZ_CP090978:c2685297-2685022 [Paenibacillus sp. YPD9-1]
ATGAGAGAAAGAAAACGGAAAGAGGGGGTGCTCTCCATGTCGACCACCGTACAGAAATGGGGAAACAGTCTAGGAATTCG
TATTCCTAGCCAGATAGCCGAAAAGATTGCAATCAGCCAAGGTTCGGAAGTTGACTTGATTGTGGGTGATGATCATTCGC
TCATTGTAATTCCCAAAAAGAAAAAGCCGACATTGGAAGAATTGTTGGCCCAATGCAAAATGGAAAATAGACACGAAGAA
GTGACTTTCGGTGTAGAAGGGAAGGAATTACTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References