Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3166578..3167126 Replicon chromosome
Accession NZ_CP069076
Organism Mycobacterium tuberculosis strain N0031

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag JN136_RS15095 Protein ID WP_003414602.1
Coordinates 3166863..3167126 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag JN136_RS15090 Protein ID WP_003414599.1
Coordinates 3166578..3166859 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN136_RS15065 3162201..3163058 - 858 WP_003899513.1 type I methionyl aminopeptidase -
JN136_RS15070 3163100..3163684 - 585 WP_003414585.1 DUF1707 domain-containing protein -
JN136_RS15075 3163788..3164036 + 249 WP_003913411.1 antitoxin VapB23 -
JN136_RS15080 3164033..3164413 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
JN136_RS15085 3164495..3166306 - 1812 WP_003414596.1 penicillin-binding protein -
JN136_RS15090 3166578..3166859 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
JN136_RS15095 3166863..3167126 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN136_RS15100 3167499..3168353 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
JN136_RS15105 3168409..3169572 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
JN136_RS15110 3169589..3170803 - 1215 WP_003414610.1 zinc metalloprotease Rip -
JN136_RS15115 3170811..3172052 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T189756 WP_003414602.1 NZ_CP069076:3166863-3167126 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T189756 NZ_CP090978:755063-755413 [Paenibacillus sp. YPD9-1]
TTGATTGTGAAACGTGGCGATGTGTTTTTCGCAGATCTTTCGCCGGTGGTAGGGTCGGAGCAGGGAGGCGTTCGTCCTGT
TCTAGTCATCCAAAATGATATCGGCAACCGCTTTAGCCCTACCGTGATCGTGGCTGCGATTACGGCGCAAATCCAGAAGG
CAAAGCTGCCTACGCATGTAGAAATCGATGCGGAGACCCACGGATTCGACCGAGATTCTGTGATTCTGTTGGAACAGATT
CGAACGATCGACAAGCAGCGGCTTACGGACAAAATCACGCATTTGGATGAAGAAACGATGCGGAAAGTTGACGACGCTTT
GCAAATTAGCGTGGGACTGATAGAATTTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT189756 WP_003414599.1 NZ_CP069076:3166578-3166859 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT189756 NZ_CP090978:754808-755059 [Paenibacillus sp. YPD9-1]
ATGATTAGTTTACCTGACAATTTGTTGCAAGAAGTCGATGGAATAGTTGAGAAGGAGAACTCGAATCGAAGCGAGTTTAT
TCGCCAGGCGATGAAGCTCTATTTGATCGAGCGCAAAAAGCGCAGTATTCGCGAATCTATGCAGCGCGGTTACATGGAAA
TGGCCAAAATCAATCTCAGTATGGCATCTGAGGCGTTTCAAGCGGAGGAAGATGCCGATTCGACGGTGGATCGCTTAGTA
AGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References